Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP226] to Human CALD1 / Caldesmon
Mouse Monoclonal (IgG1) to Duck CALD1 / Caldesmon
Duck, Human, Chicken
Western blot, ELISA
Duck CALD1 / Caldesmon
Duck, Human, Chicken (tested or 100% immunogen sequence identity)
Protein A purified
Specificity and Use
Duck gizzard caldesmon (heavy type).
Reacts with the high molecular weight (120-150 kD) and a low molecular weight (71-80 kD) forms of caldesmon, an actin interacting and calmodulin binding protein found in smooth muscle and other cell types.
PBS, pH 7.2, 0.09% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin.