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CALB2 / Calretinin

calbindin 2

Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin 2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31520 Da, and shares 58% identical residues with human calbindin 1. Calbindin 2 contains five presumably active and one presumably inactive calcium-binding domains. Comparison with the partial sequences available for chick and guinea pig calbindin 2 reveals that the protein is highly conserved in evolution. The calbindin 2 message was detected in the brain, while absent from heart muscle, kidney, liver, lung, spleen, stomach and thyroid gland. There are two additional forms of alternatively spliced calbindin 2 mRNAs encoding C-terminally truncated proteins. Exon 7 can splice to exon 9, resulting in a frame shift and a translational stop at the second codon of exon 9, and encoding calretinin-20k. Exon 7 can also splice to exon 10, resulting in a frame shift and a translational stop at codon 15 of exon 10, and encoding calretinin-22k. The truncated proteins are able to bind calcium.

Gene Name: calbindin 2
Synonyms: CALB2, 29 kDa calbindin, CAL2, Calretinin, CAB29, Calbindin 2, Calbindin D29K, CR
Target Sequences: NM_001740 NP_001731.2 P22676

Publications (1)

1
BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma. Shrestha R, Nabavi N, Lin YY, Mo F, Anderson S, Volik S, Adomat HH, Lin D, Xue H, Dong X, Shukin R, Bell RH, McConeghy B, Haegert A, Brahmbhatt S, Li E, Oo HZ, Hurtado-Coll A, Fazli L, Zhou J, McConnell Y, McCart A, Lowy A, Morin GB, Chen T, Daugaard M, Sahinalp SC, Hach F, Le Bihan S, Gleave ME, Wang Y, Churg A, Collins CC. Genome medicine. 2019 February;11:8. [Full Text Article] [PubMed:30777124] [PMC:PMC6378747]

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Antibodies (65)
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CALB2 / Calretinin (94)
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CALB2 / Calretinin Antibody
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CALB2 / Calretinin Sheep anti-Rat Polyclonal Antibody
Mouse, Rat, Primate, Human
IF, IHC, WB
Unconjugated
100 µl/$469
CALB2 / Calretinin Antibody - Calretinin antibody IHC-paraffin: Mouse Brain Tissue.
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa234-262) Antibody
Mouse, Guinea pig, Rat, Pig, Horse, Chimpanzee, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CALB2 / Calretinin Antibody - IHC-P: Calretinin antibody testing of human rectal cancer tissue
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa4-18) Antibody
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
CALB2 / Calretinin Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CALB2 / Calretinin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
Cancer Pathology
Cancer
CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa4-18) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$723
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CALB2 / Calretinin Mouse anti-Human Monoclonal (1F5H1) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
CALB2 / Calretinin Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CALB2 / Calretinin Antibody - IHC testing of FFPE human Mesothelioma with Calbindin 2 antibody (clone CALB2/2685). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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CALB2 / Calretinin Mouse anti-Human Monoclonal (CALB2/2685) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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CALB2 / Calretinin Sheep anti-Guinea pig Polyclonal Antibody
Guinea pig
IHC-Fr, WB
Unconjugated
0.1 ml/$663
CALB2 / Calretinin Antibody - CALB2 / Calretinin antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
CALB2 / Calretinin Antibody - Western blot of recombinant CALB2 / Calretinin.
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (aa28-248) Antibody
Mouse, Rat, Pig, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
CALB2 / Calretinin Antibody - Immunofluorescence of paraformaldehyde-fixed A431, using Calretinin antibody at 1:200 dilution.
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CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$450
CALB2 / Calretinin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
Cancer Pathology
Cancer
CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
CALB2 / Calretinin Antibody - ICC/IF analysis of CALB2 in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CALB2 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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CALB2 / Calretinin Mouse anti-Human Monoclonal (AT5C5) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
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CALB2 / Calretinin Mouse anti-Rat Monoclonal Antibody
Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µg/$854
CALB2 / Calretinin Protein - Purified recombinant protein CALB2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
31.4 kDa
20 µg/$1,107
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
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E. coli
6His, N-terminus
27 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
CALB2 / Calretinin Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer tissue  using CALB2 Polyclonal Antibody at dilution of 1:25(×200)
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CALB2 / Calretinin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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CALB2 / Calretinin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
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CALB2 / Calretinin Mouse anti-Human Monoclonal (7H1G3) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
Viewing 1-25 of 94 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).