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CACNA2D3 / Alpha-2/Delta-3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNA2D3 / Alpha-2/Delta-3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
| Gene Name: | calcium channel, voltage-dependent, alpha 2/delta subunit 3 |
| Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit 2 / delta |
| Synonyms: | CACNA2D3, Cacnad3, HSA272268, Alpha2delta-3 |
| Target Sequences: | NM_018398 NP_060868.2 Q8IZS8 |
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