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Human c-Src Kinase / CSK | |
Mouse | |
Human (tested or 100% immunogen sequence identity) | |
IgG1 Monoclonal [CSK-04] | |
Unconjugated | |
Purified | |
Unmodified |
Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450. | |
aa330-450 | |
C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase. One of its major functions is to specifically phosphorylate a conserved C-terminal tyrosine of Src family kinases thereby down-regulating their kinase activity. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein). |
PBS, pH 7.4, 15 mM sodium azide | |
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles. | |
For research use only. |
CSK Antibody, C-src tyrosine kinase Antibody, C-Src kinase Antibody, Protein-tyrosine kinase CYL Antibody, Tyrosine-protein kinase CSK Antibody, C-SRC Antibody, Cytoplasmic tyrosine kinase Antibody
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation.