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Anti-c-Src Kinase / CSK Antibody (aa330-450, clone CSK-04) LS-C204153
Most Popular c-Src Kinase / CSK Antibodies
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Details
| Human c-Src Kinase / CSK | |
| Mouse | |
| Human (tested or 100% immunogen sequence identity) | |
| IgG1 Monoclonal [CSK-04] | |
| Unconjugated | |
| Purified | |
| Unmodified |
Applications
- Western blot
- Immunoprecipitation
Specificity and Use
| Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450. | |
| aa330-450 | |
| C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase. One of its major functions is to specifically phosphorylate a conserved C-terminal tyrosine of Src family kinases thereby down-regulating their kinase activity. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein). |
Packaging
| PBS, pH 7.4, 15 mM sodium azide | |
| Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. | |
| For research use only. |
About c-Src Kinase / CSK
P41240
NM_004383
NP_004374.1
CSK Antibody, C-src tyrosine kinase Antibody, C-Src kinase Antibody, Protein-tyrosine kinase CYL Antibody, Tyrosine-protein kinase CSK Antibody, C-SRC Antibody, Cytoplasmic tyrosine kinase Antibody
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation.
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Date Requested: 8/22/2017
Date Requested: 8/22/2017
