c-Met

met proto-oncogene

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

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Products

Antibodies (198)

Proteins (22)

ELISA Kits (21)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (6)

Over-Expression Lysate (4)

Primary (198)

Recombinant (18)

Sandwich (10)

Sandwich Phosphorylation (1)

Target

c-Met (241)

Reactivity

Human (194)

Mouse (95)

Rat (49)

Bat (1)

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Bind (1)

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Func (1)

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rabbit (132)

mouse (65)

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IHCPlus (4)

Isotype

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IgG1 (53)

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Clonality

monoclonal mc (71)

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261 (1)

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aa1092-1379 (8)

aa570-885 (8)

pTyr1234 (8)

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aa125-421 (6)

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1290-1370 aa (2)

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1170-1250 aa (1)

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950-1030 aa (1)

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aa1201-1250 (1)

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aa976-1025 (1)

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No (238)

Yes (3)

Sample Type

Adherent Cell Cultures (4)

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Tag

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Source

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Purification

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Biologically Active

Biologically active (2)

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IHC-plus™ c-Met Antibody (Cytoplasmic Domain) LS-B2812

(5.0) Rating

(3) Publication(s)

Antibody:

c-Met Mouse anti-Human Monoclonal (Cytoplasmic Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

50 µl/$615

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c-Met Antibody (clone 6AT203) LS-C96426

(4.0) Rating

(1) Publication(s)

Antibody:

c-Met Mouse anti-Human Monoclonal (6AT203) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ c-Met Antibody (C-Terminus) LS-B3345

(4.0) Rating

Antibody:

c-Met Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

250 µl/$505

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IHC-plus™ c-Met Antibody (clone 4AT44) LS-B6889

(4.0) Rating

Antibody:

c-Met Mouse anti-Human Monoclonal (4AT44) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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c-Met Antibody (PE) LS-C486962

Antibody:

c-Met Rabbit anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$233; 100 Tests/$263

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c-Met Antibody (clone 6AT1785) LS-C96427

Antibody:

c-Met Mouse anti-Human Monoclonal (6AT1785) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse/Human/Rat Phospho-c-Met ELISA Kit - LS-F340

Type:

Sandwich Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$728

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Mouse/Human/Rat Phospho-c-Met (Tyr1234) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1564

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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c-Met Antibody (clone 5E9C4) LS-C682401

Antibody:

c-Met Mouse anti-Human Monoclonal (5E9C4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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c-Met Antibody (clone 5E9B7) LS-C682403

Antibody:

c-Met Mouse anti-Human Monoclonal (5E9B7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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c-Met Antibody (phospho-Tyr1349/1356) LS-C60102

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1349/1356) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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Human c-Met Protein (Recombinant 6His, C-terminus) - LS-G137063

Source:

E. coli

Tag:

6His, C-terminus

Molecular Weight:

59.4 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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c-Met Antibody LS-C499316

Antibody:

c-Met Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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c-Met Antibody (phospho-Tyr1356) LS-C96910

(4.0) Rating

(1) Publication(s)

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1356) Antibody

Reactivity:

Human

Applications:

DB

Format:

Unconjugated

Price:

400 µl/$393

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c-Met Antibody (Tyr1234, Azide-free) LS-C72459

Antibody:

c-Met Mouse anti-Human Monoclonal (Tyr1234) (Azide-free) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated, Azide-free

Price:

100 µl/$813

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c-Met Antibody (aa276-325) LS-C199258

Antibody:

c-Met Rabbit anti-Human Polyclonal (aa276-325) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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c-Met Antibody (phospho-Tyr1003) LS-C800988

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1003) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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c-Met Antibody (PE) LS-C486541

Antibody:

c-Met Rabbit anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$233; 100 Tests/$263

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c-Met Antibody (phospho-Tyr1234/Tyr1235, Agarose) LS-C130724

Antibody:

c-Met Rabbit anti-Human Monoclonal (pTyr1234/Tyr1235) (Agarose) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Agarose Conjugated

Price:

400 µl/$702

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IHC-plus™ c-Met Antibody (aa1316-1365) LS-B8031

(4.0) Rating

Antibody:

c-Met Rabbit anti-Human Polyclonal (aa1316-1365) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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Human c-Met Protein (Recombinant 6His, C-terminus) (Glu25-Thr932) - LS-G51887

Source:

HEK 293 Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

102.5kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$905; 1 mg/$1,203

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c-Met Antibody (phospho-Tyr1349) LS-C96909

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1349) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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c-Met Antibody (clone 4AT44) LS-C45687

Antibody:

c-Met Mouse anti-Human Monoclonal (4AT44) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$938

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c-Met Antibody (phospho-Tyr1003) LS-C37359

Antibody:

c-Met Rabbit anti-Human Monoclonal (pTyr1003) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$702

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c-Met Antibody (phospho-Tyr1234) LS-C117416

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1234) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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