The Immunohistochemistry Antibody Company
|Human, Monkey, Mouse, Rat, Bovine, Dog, Horse (tested or 100% immunogen sequence identity)|
|c-CBL antibody was raised against synthetic peptide corresponding to the sequence of human c-Cbl around 700 (DTEYMTP). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Elephant, Panda, Porcine, Bovine, Dog, Horse (100%).|
|Reacts specifically with c-Cbl. The antibody was evaluated by western blot and ELISA. By western blot, an immunoreactive band around 120 kD was detected from Raji whole cell lysate.|
|PBS, pH 7.4, 0.05% sodium azide|
|Store at 4°C. Do not freeze.|
|For research use only.|
CBL Antibody, C-CBL Antibody, Oncogene CBL2 Antibody, RING finger protein 55 Antibody, Proto-oncogene c-Cbl Antibody, RNF55 Antibody, CBL2 Antibody, FRA11B Antibody, NSLL AntibodyAdapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.