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Anti-c-CBL Antibody (phospho-Tyr674) LS-C198743

Ordering

Wt. Vol. Conc. Price
- 20 µl - $205
- 50 µl - $255
- 100 µl - $315
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular c-CBL Antibodies

Anti-c-CBL Antibody (clone 3B12) IHC-plus™ LS-B11866
Mouse Monoclonal [clone 3B12] (IgG1) to Human c-CBL
Human, Mouse, Rat
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human c-CBL
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human c-CBL
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin
  • Western blot
  • ELISA

Specificity and Use

c-CBL antibody was raised against synthetic peptide derived from human CBL around the phosphorylation site of Tyr674.
pTyr674
CBL (Phospho-Tyr674) Antibody detects endogenous levels of CBL only when phosphorylated at tyrosine674.

Packaging

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Store at -20°C.
For research use only.

About c-CBL

P22681 NM_005188 NP_005179.2

CBL Antibody, C-CBL Antibody, Oncogene CBL2 Antibody, RING finger protein 55 Antibody, Proto-oncogene c-Cbl Antibody, RNF55 Antibody, CBL2 Antibody, FRA11B Antibody, NSLL Antibody

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.

Immunohistochemistry

Immunohistochemistry
IHC of paraffin-embedded human colon carcinoma, using CBL (Phospho-Tyr674) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot
Western blot of extracts from HepG2 cells treated with Na2VO3 0.3nM 40', using CBL (Phospho-Tyr674) Antibody. The lane on the right was incubated with synthetic peptide.

Requested From: United States
Date Requested: 12/8/2016

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