Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.
Western Blot analysis of CBL expression in transfected 293T cell line by CBL monoclonal antibody (M01), clone 6D12.Lane 1: CBL transfected lysate (Predicted MW: 99.6 KDa).Lane 2: Non-transfected lysate.
CBL monoclonal antibody (M01), clone 6D12 Western Blot analysis of CBL expression in K-562.
Immunoprecipitation of CBL transfected lysate using anti-CBL monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with CBL monoclonal antibody.
Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged CBL is 0.1 ng/ml as a capture antibody.