Human BRCC3 / BRCC36

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Affinity purified

Unmodified

An 18 amino acid peptide near the N-Terminus of human BRCC36.

N-Terminus

AHP1465 recognizes human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7kD nuclear protein. BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. Studies have demonstrated that BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation. Research has shown that BRCC36 is aberrantly expressed in the majority of breast tumors indicating a potential role in the pathogenesis of the disease. It has been hypothesized that BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumors.

• IHC - Paraffin
• Western blot (0.5 - 1 µg/ml)

Western Blot: LS-C56931 detects a band of approximately 36kD in MCF7 cell lysates.

PBS, 0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P46736 NCBI: NM_024332 NP_077308.1