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Anti-BRCC3 / BRCC36 Antibody (N-Terminus) LS-C56931


Wt. Vol. Conc. Price
100 µg - - Unavailable

Most Popular BRCC3 / BRCC36 Antibodies

Anti-BRCC3 / BRCC36 Antibody (N-Terminus) IHC-plus™ LS-B1339
Rabbit Polyclonal (IgG) to Human BRCC3 / BRCC36
Human, Mouse, Rat
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-BRCC3 / BRCC36 Antibody (clone AT3B1) IHC-plus™ LS-B3588
Mouse Monoclonal [clone AT3B1] (IgG1,k) to Human BRCC3 / BRCC36
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image
Anti-BRCC3 / BRCC36 Antibody (aa266-316) LS-C286921
Rabbit Polyclonal (IgG) to Human BRCC3 / BRCC36
Human, Horse, Pig
IHC - Paraffin, Immunofluorescence
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human BRCC3 / BRCC36
Human, Mouse, Rat
Western blot


Human BRCC3 / BRCC36
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Affinity purified


Western blot (0.5 - 1 µg/ml)

Specificity and Use

BRCC3 / BRCC36 antibody was raised against an 18 amino acid peptide from near the amino terminus of human BRCC36.
AHP1465 recognizes human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7kD nuclear protein. BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. Studies have demonstrated that BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation. Research has shown that BRCC36 is aberrantly expressed in the majority of breast tumors indicating a potential role in the pathogenesis of the disease. It has been hypothesized that BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumors.
Western Blot: LS-C56931 detects a band of approximately 36kD in MCF7 cell lysates.


PBS, 0.02% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About BRCC3 / BRCC36

P46736 NM_024332 NP_077308.1

BRCC3 Antibody, C6.1A Antibody, BRCC36 Antibody, BRISC complex subunit BRCC36 Antibody, BRCA1-A complex subunit BRCC36 Antibody, CXorf53 Antibody, RP11-143H17.2 Antibody

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).

Requested From: 
Date Requested: 3/29/2017

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