Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4H9] (IgG1) to Human BRCA1
Western blot, Immunoprecipitation
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [4H9]
Protein G purified
Specificity and Use
BRCA1 antibody was raised against gST fusion protein expressed in E. coli corresponding to aa 762-1315 of full-length BRCA1.
full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the delta exon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation
BRCA1 Antibody, BROVCA1 Antibody, BRCC1 Antibody, Breast cancer 1, early onset Antibody, PPP1R53 Antibody, PSCP Antibody, PNCA4 Antibody, RING finger protein 53 Antibody, RNF53 Antibody, BRCAI Antibody, Breast cancer 1 early onset Antibody, IRIS Antibody
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function.