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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BRCA1 Antibody (aa762‑1315, clone 4H9) LS‑C53342
Antibody
BRCA1 antibody LS-C53342 is an unconjugated mouse monoclonal antibody to human BRCA1. Validated for IP and WB.
Catalog
Size
Price
LS-C53342-50
50 µg
Unavailable

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Applications: Western blot, ELISA

Product Description

BRCA1 antibody LS-C53342 is an unconjugated mouse monoclonal antibody to human BRCA1. Validated for IP and WB.
About BRCA1
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. P38398 NM_007294 NP_009225.1

BRCA1 Antibody, BROVCA1 Antibody, BRCC1 Antibody, Breast cancer 1, early onset Antibody, PPP1R53 Antibody, PSCP Antibody, PNCA4 Antibody, RING finger protein 53 Antibody, RNF53 Antibody, BRCAI Antibody, Breast cancer 1 early onset Antibody, IRIS Antibody


Specifications

Target
Human BRCA1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [4H9]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot
  • Immunoprecipitation
Immunogen
BRCA1 antibody was raised against gST fusion protein expressed in E. coli corresponding to aa 762-1315 of full-length BRCA1.
Epitope
aa762-1315
Specificity
full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the delta exon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation
Presentation
PBS.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/23/2018

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