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Anti-BMP6 Antibody (aa382-513) LS-C149863

Ordering

Wt. Vol. Conc. Price
100 µg - - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular BMP6 Antibodies

Anti-BMP6 Antibody (aa40-55) IHC-plus™ LS-B789
Rabbit Polyclonal to Human BMP6
Human
IHC - Paraffin, ELISA
Unconjugated
Immunohistochemistry Image
Anti-BMP6 Antibody LS-C77131
Mouse Monoclonal (IgG2b) to Human BMP6
Human
Western blot, ELISA
Unconjugated
Anti-BMP6 Antibody (aa382-513) LS-C149863
Goat Polyclonal (IgG) to Human BMP6
Human
IHC - Paraffin, Western blot, Neutralization
Unconjugated
Neutralization Image

100% Guaranteed 100% Guaranteed
Goat Polyclonal (IgG) to Human BMP6
Human
IHC - Paraffin, Western blot, Neutralization
Unconjugated

Details

Human BMP6
Goat
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 - 15 µg/ml)
  • Western blot (0.1 µg/ml)
  • Neutralization

Specificity and Use

BMP6 antibody was raised against e. coli-derived recombinant human BMP-6 Gln382-His513 Accession # P22004.
aa382-513
Detects human BMP-6 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human.
Western Blot, 0.1 µg/ml, Recombinant Human BMP-6. Immunohistochemistry, 5-15 µg/ml, Immersion fixed paraffin-embedded sections of human lung. Neutralization, Measured by its ability to neutralize BMP-6-induced alkaline phosphatase production in the ATDC5 mouse. chondrogenic cell line. The Neutralization Dose (ND50) is typically 5-20 µg/ml in the presence of 300 ng/ml Recombinant Human BMP-6 and 50 µg/ml L-ascorbic acid.

Packaging

Lyophilized from 0.2 um filtered solution in PBS, trehalose
Sterile PBS. Resuspend to 500 ul
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
For research use only.

About BMP6

P22004 NM_001718 NP_001709.1

BMP6 Antibody, BMP-6 Antibody, Bone morphogenetic protein 6 Antibody, VG-1-related protein Antibody, VGR1 Antibody, VG-1-R Antibody, VGR Antibody, Vg1 Antibody, Vg1-related sequence Antibody, VGR-1 Antibody

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development.

Neutralization

Neutralization
Alkaline Phosphatase Production Induced by BMP-6 and Neutralization by Human BMP-6 Antibody. Recombinant Human BMP-6 induces alkaline phosphatase production in the the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-6 (300 ng/ml) is neutralized (green line) by increasing concentrations of Goat Anti-Human BMP-6 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 5-20 ug/ml in the presence of L-ascorbic acid (50 ug/ml).
 

Requested From: United States
Date Requested: 12/7/2016

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