Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
BMP6 Antibody, BMP-6 Antibody, Bone morphogenetic protein 6 Antibody, VG-1-related protein Antibody, VGR1 Antibody, VG-1-R Antibody, VGR Antibody, Vg1 Antibody, Vg1-related sequence Antibody, VGR-1 Antibody
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development.
BMP-6 in Mouse Embryo. BMP-6 was detected in immersion fixed frozen sections of mouse embryo (15 d. p. c.) using Sheep Anti-Mouse BMP-6 Antigen Affinity-purified Polyclonal Antibody at 15 ug/ml overnight at 4°C. Tissue was stained using Anti-Sheep HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to skeletal muscle cells.
Detection of Mouse BMP-6 by Western Blot. Western blot shows lysates of NS0 mouse myeloma cell line either mock transfected or transfected with mouse BMP-6. PVDF membrane was probed with 1 ug/ml of Sheep Anti-Mouse BMP-6 Antigen Affinity-purified Polyclonal Antibody followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody. For additional reference, Recombinant Mouse BMP-6 (10 ng/lane) was included. A specific band was detected for BMP-6 at approximately 20kD (as indicated). This experiment was conducted under reducing conditions.
Requested From: United States
Date Requested: 1/23/2017