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Anti-BIRC7 / Livin Antibody (clone 88C570) IHC-plus™ LS-B2018

Note: This antibody replaces LS-C562, LS-C71765

Ordering

Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Most Popular BIRC7 / Livin Antibodies

Anti-BIRC7 / Livin Antibody (clone 88C570) IHC-plus™ LS-B2018
Mouse Monoclonal [clone 88C570] (IgG1) to Human BIRC7 / Livin
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-BIRC7 / Livin Antibody (aa199-217) LS-C148274
Rabbit Polyclonal to Human BIRC7 / Livin
Human, Monkey, Mouse
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 88C570] (IgG1) to Human BIRC7 / Livin
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human BIRC7 / Livin
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [88C570]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • Western blot (1 - 2 µg/ml)

Specificity and Use

BIRC7 / Livin antibody was raised against recombinant human livin protein.
The Livin antibody, clone 88C570 has been shown to recognize both Livin alpha (~39 kD) and Livin beta (~37 kD) isoforms (Nachmias et al, 2003). 2. also recognizes the 30 kD (p30-Livin alpha) and 28 kD (p28-Livin beta) apoptotic cleavage fragments of Livin alpha and beta, respectively (Nachmias et al, 2003). Apoptotic cleavage fragments of Livin have also been referred to as truncated livin (tLivin) (Nachmias et al, 2007). 3. The specificity has been validated using Livin shRNA (Quiping et al, 2004).
Immunohistochemistry: LS-B2018 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2018 was determined to be 10 ug/ml.

Packaging

PBS containing 0.05% BSA and 0.05% sodium azide
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About BIRC7 / Livin

Q96CA5 NM_022161 NP_071444.1

BIRC7 Antibody, KIAP Antibody, Livin inhibitor of apoptosis Antibody, MLIAP Antibody, ML-IAP Antibody, RNF50 Antibody, RING finger protein 50 Antibody, LIVIN Antibody

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.

Immunohistochemistry

Immunohistochemistry
Anti-BIRC7 / Livin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2018 concentration 10 ug/ml.

Western blot

Western blot
Western blot detection of Livin in A) Livin transfected cell lysate and B) U266 cell lysate. A protein band of approximate molecular weight of 31 kDa is detected using antibody at 2 ug/ml dilution.

Requested From: United States
Date Requested: 12/6/2016

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