BHLHB2 / DEC1

basic helix-loop-helix family, member e40

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

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Products

Antibodies (47)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (47)

Recombinant (2)

Target

BHLHB2 / DEC1 (51)

Reactivity

Human (46)

Mouse (22)

Rat (5)

Chimpanzee (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Application

IHC (14)

IHC-P (8)

WB (41)

ELISA (16)

ICC (1)

IF (4)

IP (5)

Host

rabbit (28)

mouse (19)

Product Group

IHCPlus (1)

Isotype

IgG (20)

IgG1 (13)

IgG2b,k (6)

Clonality

monoclonal mc (19)

polyclonal pc (28)

Clone

OTI10H1 (2)

OTI1F10 (2)

OTI2B6 (2)

OTI2C7 (2)

OTI2C9 (2)

OTI4C4 (2)

OTI6D6 (1)

Format

APC Conjugated (2)

Biotin Conjugated (5)

Carrier-free (6)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (27)

Epitope

aa1-313 (13)

aa22-51 (7)

C-Terminus (6)

aa249-298 (4)

aa350-C-term (2)

aa130-230 (1)

Publications

No (51)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ BHLHB2 / DEC1 Antibody (C-Terminus) LS-B2222

(4.0) Rating

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$460

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BHLHB2 / DEC1 Antibody (C-Terminus, Biotin) LS-C142758

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

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BHLHB2 / DEC1 Antibody (C-Terminus, DY650) LS-C142759

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

DY650 Conjugated

Price:

0.1 ml/$416

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BHLHB2 / DEC1 Antibody (C-Terminus, DY488) LS-C142760

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

DY488 Conjugated

Price:

0.1 ml/$416

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BHLHB2 / DEC1 Antibody (C-Terminus, DY550) LS-C142762

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

DY550 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY650
• DY488
• DY550

• Unconjugated
• Biotin
• DY650
• More...
  • DY488
  • DY550

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BHLHB2 / DEC1 Antibody LS-C482634

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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BHLHB2 / DEC1 Antibody (aa249-298) LS-C30309

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa249-298) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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BHLHB2 / DEC1 Antibody LS-C334780

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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BHLHB2 / DEC1 Antibody LS-C498436

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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BHLHB2 / DEC1 Antibody LS-C764871

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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BHLHB2 / DEC1 Antibody (aa350-C-term) LS-C287517

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa350-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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BHLHB2 / DEC1 Antibody (C-Terminus) LS-C144897

Antibody:

BHLHB2 / DEC1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

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BHLHB2 / DEC1 Antibody (aa1-313, clone OTI10H1) LS-C795340

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa1-313) (OTI10H1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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BHLHB2 / DEC1 Antibody (aa1-313, clone OTI10H1, Carrier-free) LS-C798768

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa1-313) (Carrier-free) (OTI10H1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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BHLHB2 / DEC1 Antibody (aa130-230) LS-C306541

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa130-230) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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BHLHB2 / DEC1 Antibody (HRP) LS-C541089

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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BHLHB2 / DEC1 Antibody (Biotin) LS-C520958

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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BHLHB2 / DEC1 Antibody (FITC) LS-C531003

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

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BHLHB2 / DEC1 Antibody (PE) LS-C649201

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

Select

BHLHB2 / DEC1 Antibody (APC) LS-C512743

Antibody:

BHLHB2 / DEC1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

BHLHB2 / DEC1 Antibody (aa350-C-term) LS-C286676

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa350-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$483

Select

BHLHB2 / DEC1 Antibody (aa22-51) LS-C329259

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

BHLHB2 / DEC1 Antibody (aa22-51, FITC) LS-C252557

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

BHLHB2 / DEC1 Antibody (aa22-51, APC) LS-C252555

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

BHLHB2 / DEC1 Antibody (aa22-51, PE) LS-C252558

Antibody:

BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC
• APC
• PE

• Unconjugated
• FITC
• APC
• More...
  • PE

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