Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Formalin-fixed, paraffin-embedded normal human colon epithelium tissue section stained for Bcl-X expression using LS-C148232 at 1:2000. Hematoxylin-Eos in counterstain. A course granular Bcl-X staining pattern associated with the mitochondria is observed.
Formalin-fixed, paraffin-embedded human colon carcinoma tissue section stained for Bcl-X expression using LS-C148232 at 1:2000. Hematoxylin-Eosin counterstain.
Western blot of Bcl-X using LS-C148232. Lane 1. lysates from isolated rat liver mitochondria. Lanes 2-4. rat brain tissue lysates: cortex (lane 2), basal ganglia (lane 3), and cerebellum (lane 4). The antibody detected Bcl-XL at ~30 kD.