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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BCL2L1 / BCL‑XL Antibody (C‑Terminus) IHC‑plus™ LS‑B451
Note: This antibody replaces LS-C440, LS-C125172
BCL-XL antibody LS-B451 is an unconjugated rabbit polyclonal antibody to human BCL-XL (BCL2L1). Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B451-50
50 µg (1 mg/ml)
Unavailable

Popular BCL2L1 / BCL-XL Products

Antibody
Species: Human, Mouse, Rat, Dog, Hamster, Pig
Applications: IHC, IHC - Paraffin, Western blot
Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1175 concentration 10 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Detection of Bcl-x in A431 whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Cat, Dog, Hamster, Pig, Rabbit, Sheep
Applications: Western blot
Western blot Image
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit
Applications: Western blot

Product Description

BCL-XL antibody LS-B451 is an unconjugated rabbit polyclonal antibody to human BCL-XL (BCL2L1). Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
About BCL2L1 / BCL-XL
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Q07817 NM_001191 NP_001182.1

BCL2L1 Antibody, Apoptosis regulator Bcl-X Antibody, Bcl-xL Antibody, BCL-XL/S Antibody, BCLXS Antibody, Bcl-2-like protein 1 Antibody, BCL2-like 1 Antibody, BCL2L Antibody, Bcl-X Antibody, Bcl-xS Antibody, BCLXL Antibody, PPP1R52 Antibody, Bcl2-L-1 Antibody, BCLX Antibody


Specifications

Target
Human BCL2L1 / BCL-XL
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Ion exchange chromatography
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2.5 µg/ml)
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Blocking Peptide
LS-E30075 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-B451. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Usage
Immunohistochemistry: LS-B451 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B451 was determined to be 2.5 ug/ml.
Presentation
PBS, 0.02% sodium azide.
Storage
Store at 4°C for 3 months and -20°C, stable for up to 1 year. Avoid repeated freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.

Western blot

Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.
Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.

Western blot

Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.
Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.

Western blot

Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.
Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.

Western blot

Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.
Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.

Western blot

Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.
Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.

Western blot

Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.
Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 2.5 ug/ml.

Immunohistochemistry

Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.
Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B451 concentration 5 ug/ml.

Western blot

Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.
Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 µg/mL.

Western blot

Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.
Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.


Requested From: 
Date Requested: 6/19/2018

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