BACE2 antibody LS-C543646 is an HRP-conjugated rabbit polyclonal antibody to BACE2 from human, mouse and rat. Validated for WB.
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Also available conjugated with AP
BACE2 antibody was raised against synthetic peptide corresponding to amino acids 44-59 of human BACE2
Recognizes an epitope within the N-terminal region of BACE2, a homologue of the beta-site APP cleaving enzyme (BACE). BACE2 has been reported to cleave the beta-amyloid precursor protein (APP) at the beta-site, producing amyloid-beta protein (ABeta). Accumulation of ABeta plaques in the cerebral cortex play an important role in the pathogenesis of Alzheimer's disease, particularly in individuals bearing the Flemish mutation. Species cross-reactivity Mouse, rat.