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Anti-BACE1 / BACE Antibody LS-C74520

Catalog Size Price
LS-C74520-100 100 µg (0.5 mg/ml) Unavailable

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100% Guaranteed
Mouse Monoclonal (IgG1) to Human BACE1 / BACE
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Human BACE1 / BACE
Human, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Protein G purified


  • Western blot
  • Immunoprecipitation
  • Neutralization

Specificity and Use

BACE1 / BACE antibody was raised against nS0-derived rhBACE-1 ectodomain.
Recognizes human BACE-1 ectodomain. Species cross-reactivity: Mouse.
Suitable for use in ELISA, Immunoprecipitation/ Western Blot and Neutralization. The enzyme was then assayed with a peptide substrate. 50% of the proteolytic activity was inhibited by the antibody at 10 ug/ml (IC50) under conditions in which the enzyme was present at 10 ug/ml and the substrate concentration was 10uM. Considering the molecular masses of the enzyme (75kD) and the antibody (150kD), IC50 was achieved at ~0.5:1 molar ratio of the antibody to the enzyme. Did not inhibit rhCathepsin D activity under the same conditions.


Lyophilized, PBS, pH 7.4, 5% trehalose
200 µl Sterile PBS
4°C or -20°C, Avoid freeze-thaw cycles.
For research use only.

About BACE1 / BACE

P56817 NM_012104 NP_036236.1

BACE1 Antibody, APP beta-secretase Antibody, Asp 2 Antibody, ASP2 Antibody, Aspartyl protease 2 Antibody, Aspartylprotease 2 Antibody, Beta-secretase Antibody, Beta-site APP-cleaving enzyme Antibody, BACE Antibody, HSPC104 Antibody, KIAA1149 Antibody, B-Secretase Antibody, Beta-secretase 1 Antibody, Memapsin-2 Antibody

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Requested From: 
Date Requested: 5/25/2018

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