Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Mouse Monoclonal (IgG2a) to Human B2M / Beta 2 Microglobulin
Human
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Unconjugated
Mouse Monoclonal (IgG2a) to Human B2M / Beta 2 Microglobulin
Human
Western blot, Flow Cytometry, ELISA
Unconjugated
Details
Human B2M / Beta 2 Microglobulin
Mouse
Human (tested or 100% immunogen sequence identity)
Mouse, Bovine, Dog, Rabbit, Chicken
IgG2a Monoclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified
Applications
Western blot
Flow Cytometry
ELISA
Specificity and Use
Beta-2 microglobulin from human urine.
Recognizes native beta 2 microglobulin which is a component of MHC class I molecules, which are present on all nucleated cells. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Also known as B2M, it has been suggested that this protein can be used as a prognostic marker for HIV infection.
Packaging
PBS, 0.09% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.