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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AXIN1 / Axin‑1 Antibody (Internal) LS‑C20825
Antibody
Axin-1 antibody LS-C20825 is an unconjugated rabbit polyclonal antibody to human Axin-1 (AXIN1). Validated for WB.
Catalog
Size
Price
LS-C20825-100
100 µg (0.25 mg/ml)
Unavailable

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Product Description

Axin-1 antibody LS-C20825 is an unconjugated rabbit polyclonal antibody to human Axin-1 (AXIN1). Validated for WB.
About AXIN1 / Axin-1
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. O15169 AF009674 AAC51624.1

AXIN1 Antibody, Axis inhibitor 1 Antibody, AXIN Antibody, Axin 1 Antibody, Axis inhibition protein 1 Antibody, Fused, mouse, homolog of Antibody, HAxin Antibody, PPP1R49 Antibody, Axin-1 Antibody


Specifications

Target
Human AXIN1 / Axin-1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.1 - 2 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
AXIN1 / Axin-1 antibody was raised against synthetic peptide derived from the internal region of the human Axin protein. Based on amino acid sequence, this antibody is not expected to cross-react with Axin-2.
Epitope
Internal
Specificity
Reacts with the human Axin protein. On Western blots, it recognizes a doublet band at ~120-130kD. The sequence used for this antibody shares 86% sequence homology with mouse, rat, and chicken Axin. Reactivity is confirmed with human Jurkat leukemia T cell lysates.
Usage
Suitable for use in Western Blot. Western Blot: 0.1-2.0 ug/ml.
Presentation
PBS, pH 7.4, 0.1% sodium azide
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/19/2018

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