Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2b) to Human AURKA / Aurora-A
Immunofluorescence, Western blot, Immunoprecipitation (applications tested for the base form of this product only)
Human AURKA / Aurora-A
Human, Mouse (tested or 100% immunogen sequence identity)
Also available conjugated with Biotin.
Protein G purified
Western blot (1:500 - 1:1000)
(applications tested for the base form of this product only)
Specificity and Use
AURKA / Aurora-A antibody was raised against recombinant Aurora-A.
Recognizes human Aurora-A kinase, a 46kD serine/threonine kinase involved in mitotic spindle assembly. Aurora-A is reported to be overexpressed in many epithelial cancers and is thought to play an important role in tumorigenesis. Clone Recognizes an epitope within the non-catalytic N-terminal domain of Aurora-A. Clone 35C1 does not inhibit Aurora-A kinase activity.
Western Blot: LS-C44482 detects a band of approximately 46kD in human HeLa and mouse M-ICc12 cell lysates.
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes.