AURKA / Aurora-A

aurora kinase A

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

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Products

Antibodies (86)

Proteins (21)

ELISA Kits (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (12)

Primary (86)

Recombinant (9)

Sandwich (1)

Target

AURKA / Aurora-A (110)

Reactivity

Human (80)

Mouse (35)

Rat (29)

Bovine (7)

Chimpanzee (6)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (10)

Non-Human Primate (2)

Orangutan (3)

Pig (2)

Primate (1)

Rabbit (3)

Sheep (7)

Zebrafish (3)

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Application

IHC (40)

IHC-P (16)

WB (71)

Flo (5)

ELISA (36)

ICC (11)

IF (20)

IP (6)

Peptide-ELISA (8)

Host

rabbit (68)

mouse (17)

goat (1)

Product Group

IHCPlus (4)

Isotype

IgG (50)

IgG1 (9)

IgG1,k (2)

IgG2a,k (1)

IgG2b (2)

IgM (1)

Clonality

monoclonal mc (17)

polyclonal pc (69)

Clone

1364CT291.108.155 (1)

1F8 (3)

2D8A4 (1)

35C1 (1)

3H1 (1)

4G10 (2)

4H5A8 (1)

5F8 (1)

7A3 (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (1)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (5)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Unconjugated (67)

Epitope

pThr288 (9)

aa90-120 (7)

aa93-120 (7)

C-Terminus (5)

aa151-200 (4)

N-Terminus (3)

280-360 aa (2)

aa268-404 (2)

aa75-125 (2)

pSer342 (2)

230-310 aa (1)

Pro282 (1)

aa1-111 (1)

aa1-131 (1)

aa100-150 (1)

aa109-125 (1)

aa256-305 (1)

aa311-360 (1)

aa394-403 (1)

aa50-100 (1)

p288 (1)

p342 (1)

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Publications

No (110)

Sample Type

Adherent Cell Cultures (2)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (3)

His (1)

Myc-DDK (Flag) (16)

Species

Human (15)

Source

293T Cells (6)

E. coli (1)

HEK 293 Cells (10)

Wheat Germ Extract (4)

Purification

Purified (1)

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IHC-plus™ AURKA / Aurora-A Antibody (aa394-403) LS-B191

(4.0) Rating

Antibody:

AURKA / Aurora-A Goat anti-Human Polyclonal (aa394-403) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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AURKA / Aurora-A Antibody LS-C664380

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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Mouse/Human/Rat Phospho-AURKA / Aurora-A (Thr288) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1155

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$772

Select

IHC-plus™ AURKA / Aurora-A Antibody (aa100-150) LS-B6517

(4.0) Rating

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (aa100-150) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

AURKA / Aurora-A Antibody (aa268-404, clone 2D8A4) LS-C682496

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (aa268-404) (2D8A4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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AURKA / Aurora-A Antibody (N-Terminus, clone 35C1) LS-C44482

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (N-Terminus) (35C1) Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$395

Select

IHC-plus™ AURKA / Aurora-A Antibody (clone 7A3) LS-B3912

(4.0) Rating

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (7A3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

AURKA / Aurora-A Antibody (C-Terminus) LS-C354094

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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AURKA / Aurora-A Antibody (280-360 aa) LS-C382140

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (280-360 aa) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Human AURKA / Aurora-A (Sandwich ELISA) ELISA Kit - LS-F31977

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

AURKA / Aurora-A Antibody (phospho-Thr288) LS-C198663

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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AURKA / Aurora-A Antibody (230-310 aa) LS-C381244

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (230-310 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

AURKA / Aurora-A Antibody LS-C137035

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

Select

AURKA / Aurora-A Antibody (clone 1F8) LS-C359318

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody

Reactivity:

Rat, Primate, Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

AURKA / Aurora-A Antibody (clone 1F8) LS-C758911

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody

Reactivity:

Rat, Non-Human Primate, Human

Applications:

Flo, ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$541

Select

AURKA / Aurora-A Antibody LS-C812504

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal Antibody

Reactivity:

Rat, Human, Monkey

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

AURKA / Aurora-A Antibody (phospho-Thr288) LS-C358422

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody

Reactivity:

Mouse, Sheep, Bovine, Rat, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

AURKA / Aurora-A Antibody (clone 1F8) LS-C169310

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (1F8) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

AURKA / Aurora-A Antibody (aa1-131) LS-C677261

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (aa1-131) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

AURKA / Aurora-A Antibody (phospho-Thr288) LS-C800871

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (pThr288) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

AURKA / Aurora-A Antibody (C-Terminus) LS-B6732

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

AURKA / Aurora-A Antibody (aa268-404, clone 4H5A8) LS-C682498

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (aa268-404) (4H5A8) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

AURKA / Aurora-A Antibody LS-C180105

Antibody:

AURKA / Aurora-A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

AURKA / Aurora-A Antibody (aa1-111, clone 5F8) LS-C133953

Antibody:

AURKA / Aurora-A Mouse anti-Human Monoclonal (aa1-111) (5F8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

Mouse/Human/Rat AURKA / Aurora-A (Cell-Based ELISA) ELISA Kit - LS-F1815

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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