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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ATXN1 / SCA1 Antibody (aa686‑699) LS‑C139784
Antibody
SCA1 antibody LS-C139784 is an unconjugated goat polyclonal antibody to SCA1 (ATXN1) from human, mouse, rat and other species. Validated for Peptide-ELISA.
Catalog
Size
Price
LS-C139784-100
100 µg
Unavailable

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Product Description

SCA1 antibody LS-C139784 is an unconjugated goat polyclonal antibody to SCA1 (ATXN1) from human, mouse, rat and other species. Validated for Peptide-ELISA.
About ATXN1 / SCA1
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. P54253 NM_000332 NP_000323.2

ATXN1 Antibody, ATX1 Antibody, Ataxin 1 Antibody, D6S504E Antibody, Ataxin-1 Antibody, SCA1 Antibody


Specifications

Target
Human ATXN1 / SCA1
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Chicken, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Peptide Enzyme-Linked Immunosorbent Assay (1:32000)
Failed Applications
  • IHC - Paraffin
Immunogen
ATXN1 / SCA1 antibody was raised against synthetic peptide C-TLKNLKNGSVKKGQ from an internal region of human ATXN1 / Ataxin-1 (NP_000323.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Bat, Horse, Pig, Opossum (100%); Turkey, Chicken, Lizard, Xenopus (93%); Panda, Dog, Platypus, Pufferfish (86%).
Blocking Peptide
LS-E27681 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C139784. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa686-699
Specificity
Human ATXN1 / Ataxin-1. Reported variants represent identical protein: NP_001121636.1, NP_000323.2
Usage
Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave bands at approx 75kD and 26kD in Mouse Fetal Brain lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 84.7kD according to NP_001186234.1 and 83.8kD according to NP_033150.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
Presentation
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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