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Anti-ATR Antibody (Ser428) LS-C92170

Catalog Size Price
LS-C92170-100 100 µg (1 mg/ml) Unavailable

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43 ATR Antibodies

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Anti-ATR Antibody (aa394-443) LS-C118345
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Anti-ATR Antibody (aa370-450) LS-C382213
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100% Guaranteed
Rabbit Polyclonal (IgG) to Human ATR
Human, Monkey, Horse, Rabbit
IHC
Unconjugated

Details

Human ATR
Rabbit
Human, Monkey, Horse, Rabbit (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC (1:50 - 1:100)

Specificity and Use

ATR antibody was raised against synthesized non-phosphopeptide derived from human ATR around the phosphorylation site of Serine 428 (G-I-SP-P-K).
Ser428
Recognizes endogenous levels of human total ATR protein.
Suitable for use in Immunohistochemistry. Immunohistochemistry: 1:50-1:100.

Packaging

PBS without Mg2+, Ca2+, pH 7.4, 0.02% sodium azide, 50% glycerol
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About ATR

Q13535 NM_001184 NP_001175.2

ATR Antibody, FRAP-related protein-1 Antibody, FCTCS Antibody, SCKL1 Antibody, MEC1 Antibody, Protein kinase ATR Antibody, Rad3 related protein Antibody, SCKL Antibody, FRAP-related protein 1 Antibody, FRP1 Antibody

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis.

Requested From: 
Date Requested: 12/17/2017

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