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ATP2A2 / SERCA2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

ATP2a2 (Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 ATPase), also known as SERCA2 (Sarcoplasmic reticulum Ca(2+)-ATPase 2), belongs to the large family of P-type cation pumps that couple ATP hydrolysis with cation transport across membranes. The ATP2a2 pump maintains low cytosolic Ca(2+) concentrations by actively transporting Ca(2+) from the cytosol into the sarco/endoplasmic reticulum lumen. Experiments on ATP2a2-null mice demonstrate that this enzyme may be important for the cardiac function. Germ-line mutations in ATP2a2 are the cause of the Darier-White disease (keratosis follicularis), which is characterized by warty papules and plaques in seborrheic areas (central trunk, flexures, scalp, and forehead), palmoplantar pits, and distinctive nail abnormalities.

Gene Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Family/Subfamily: Transporter , ATPase - P type, type IIA
Synonyms: ATP2A2, ATP2B, Calcium pump 2, DAR, SR Ca(2+)-ATPase 2, Cardiac Ca2+ ATPase, DD, SERCA2
Target Sequences: NM_001681 NP_001672.1 P16615

Publications (2)

1
T cell exosome-derived miR-142-3p impairs glandular cell function in Sjögren's syndrome. Juan Cortes-Troncoso, Shyh-Ing Jang, Paola Perez, Jorge Hidalgo, Tomoko Ikeuchi, Teresa Greenwell-Wild, Blake M Warner, Niki M Moutsopoulos, Ilias Alevizos. JCI insight. 2020 May;5: [Full Text Article] [PubMed:32376798] [PMC:PMC7253014] Related Antibodies: LS-B10343.
2
Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study. Celestino Sardu, Gaetano Santulli, Germano Guerra, Maria Consiglia Trotta, Matteo Santamaria, Cosimo Sacra, Nicola Testa, Valentino Ducceschi, Gianluca Gatta, Michele D' Amico, Ferdinando Carlo Sasso, Giuseppe Paolisso, Raffaele Marfella. Journal of Clinical Medicine. 2020 Feb;9:544. [Full Text Article] [PubMed:32079238] [PMC:PMC7074346]

☰ Filters
Antibodies (43)
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ATP2A2 / SERCA2 (52)
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ATP2A2 / SERCA2 Antibody - Anti-ATP2A2 / SERCA2 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ATP2A2 / SERCA2 Goat anti-Human Polyclonal (aa658-671) Antibody
Rabbit, Mouse, Rat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ATP2A2 / SERCA2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$834
ATP2A2 / SERCA2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ATP2A2 / SERCA2 Protein - 12.5% SDS-PAGE of human ATP2A2 stained with Coomassie Blue
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Wheat Germ Extract
GST
136.1 kDa
2 µg/$439
ATP2A2 / SERCA2 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa794-843) Antibody
Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ATP2A2 / SERCA2 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa794-843) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ATP2A2 / SERCA2 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa794-843) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
ATP2A2 / SERCA2 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa794-843) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ATP2A2 / SERCA2 Antibody - ATP2A2 antibody IHC-paraffin: Mouse Lung Tissue.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa1-32) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ATP2A2 / SERCA2 Antibody - Immunohistochemistry of paraffin-embedded rat brain using ATP2A2 Antibodyat dilution of 1:100 (40x lens).
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ATP2A2 / SERCA2 Protein - Recombinant ATPase, Ca++ TransPorting, Cardiac Muscle, Slow Twitch 2 By SDS-PAGE
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E. coli
His-GST
78.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ATP2A2 / SERCA2 Antibody - Immunohistochemistry of paraffin-embedded human heart tissue using ATP2A2 Antibody at dilution of 1:100
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
ATP2A2 / SERCA2 Antibody - ATP2A2 / SERCA2 antibody. IHC(P): Human Breast Cancer Tissue.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa665-679) Antibody
Xenopus, Bat, Rat, Horse, Rabbit, Mouse, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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ATP2A2 / SERCA2 Mouse anti-Dog Monoclonal (HRP) Antibody
Dog, Human
ICC, IHC, WB
HRP Conjugated
100 µl/$1,079
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ATP2A2 / SERCA2 Mouse anti-Dog Monoclonal (Biotin) Antibody
Dog, Human
ICC, IHC, WB
Biotin Conjugated
100 µl/$1,079
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ATP2A2 / SERCA2 Mouse anti-Dog Monoclonal (FITC) Antibody
Dog, Human
ICC, IHC, WB
FITC Conjugated
100 µl/$1,079
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ATP2A2 / SERCA2 Mouse anti-Dog Monoclonal (PE) Antibody
Dog, Human
ICC, IHC, WB
PE Conjugated
100 µl/$1,079
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ATP2A2 / SERCA2 Mouse anti-Dog Monoclonal (APC) Antibody
Dog, Human
ICC, IHC, WB
APC Conjugated
100 µl/$1,079
ATP2A2 / SERCA2 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP2A2 / SERCA2 Antibody - Western blot of ATP2A2 pAb in extracts from mouse heart tissue.
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
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ATP2A2 / SERCA2 Rabbit anti-Human Polyclonal (aa374-403) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Viewing 1-25 of 52 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).