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Anti-ATM Antibody (C-Terminus) IHC-plus™ LS-B491

Note: This antibody replaces LS-C2761

Ordering

Wt. Vol. Conc. Price
- 50 µl 2.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular ATM Antibodies

Anti-ATM Antibody (aa980-1512, clone 3E8) IHC-plus™ LS-B1684
Mouse Monoclonal [clone 3E8] (IgG1) to Human ATM
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal to Human ATM
Human
IHC - Paraffin, Western blot, Immunoprecipitation (applications tested for the base form of this product only)
Unconjugated

Details

Human ATM
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated. Also available conjugated with Biotin, DY650, DY488, DY550.
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (10 - 20 µg/ml)
  • Western blot (1:2500)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

ATM antibody was raised against a fragment of human ATM protein expressed in E. coli. The fragment relates to the C-terminal region (within the last third of the protein sequence)
C-Terminus
ATM.
Immunohistochemistry: LS-B491 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B491 was determined to be 10-20 ug/ml.

Packaging

PBS, 30% glycerol with 0.05% sodium azide as preservative
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
For research use only.

Publications (1)

1
Phospho-DeltaNp63 alpha -dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death. Ratovitski EA. FEBS letters. 2013 Aug;587:2536-41. [Full Text Article] [PubMed:23831023]

About ATM

Q13315 NM_000051 NP_000042.3

ATM Antibody, A-T mutated Antibody, ATA Antibody, ATC Antibody, ATD Antibody, ATE Antibody, AT mutated Antibody, Ataxia telangiectasia Antibody, ATDC Antibody, Serine-protein kinase ATM Antibody, AT1 Antibody, Ataxia telangiectasia mutated Antibody, TEL1 Antibody, TELO1 Antibody

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism.

Immunohistochemistry

Immunohistochemistry
Anti-ATM antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B491 concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/7/2016

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