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ATF6

activating transcription factor 6

ATF6 is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Gene Name: activating transcription factor 6
Synonyms: ATF6, ATF6-alpha, ATF6A
Target Sequences: NM_007348 NP_031374.2 P18850

Publications (2)

1
The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome. Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D'Amico G, Herman H, Hermenean A, Bucolo C, D'Amico M. PloS one. 2019 January;14:e0211005. [Full Text Article] [PubMed:30657794] [PMC:PMC6338370]
2
Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas. Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A Frank, Zun-Ji Ke, Jia Luo. Oncotarget. 2016 August;7:54303-54316. [Full Text Article] [PubMed:27527870] [PMC:PMC5342343]

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Antibodies (64)
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ATF6 (80)
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ATF6 Antibody - Anti-ATF6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
ATF6 Antibody - Anti-ATF6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ATF6 Mouse anti-Human Monoclonal (aa1-273) (70B1413.1) Antibody
Mouse, Rat, Hamster, Human
ChrIP, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ATF6 Antibody - Anti-ATF6 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ATF6 Antibody - Anti-ATF6 antibody IHC of mouse adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ATF6 Antibody - Anti-ATF6 antibody IHC of mouse adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Mouse Polyclonal (C-Terminus) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ATF6 Antibody - Anti-ATF6 antibody IHC of mouse adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
ATF6 Antibody - Anti-ATF6 antibody IHC of mouse adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ATF6 Antibody - Anti-ATF6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ATF6 Mouse anti-Human Monoclonal (3D5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ATF6 Antibody - Anti-ATF6 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ATF6 Goat anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
ATF6 Antibody - Immunofluorescent analysis of ATF6 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
ATF6 Antibody
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ATF6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
ATF6 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ATF6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
ATF6 Antibody - ATF6 antibody Western blot of HeLa lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
WB
Unconjugated
100 µl/$424
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ATF6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
ATF6 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with ATF6 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ATF6 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATF6 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ATF6 Antibody - ATF6 antibody AF6229 western blot of human samples
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ATF6 Mouse anti-Human Monoclonal (N-Terminus) (AF6229) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
25 µg/$364; 100 µg/$511
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ATF6 Rabbit anti-Human Polyclonal (aa620-670) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ATF6 Antibody - Immunohistochemistry of paraffin-embedded human esophagus using ATF6 antibody (40x lens).
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ATF6 Antibody - Immunohistochemistry - Anti-ATF6 Picoband Antibody
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ATF6 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ATF6 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATF6 Antibody - West ernBlot(WB) analysis of ATF6 pAb in extracts from mouse brain tissue, Hela, HepG2, mouse liver tissue and HL60 cells.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
ATF6 Antibody - Immunocytochemistry/Immunofluorescence: ATF6 Antibody - Antibody was tested in HeLa cells with FITC (green). Nuclei were counterstained with Dapi (blue).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ATF6 Rabbit anti-Human Polyclonal Antibody
Human
ICC, WB
Unconjugated
0.1 ml/$386
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ATF6 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Viewing 1-25 of 80 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).