ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

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Products

Antibodies (155)

ELISA Kits (18)

Proteins (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (6)

Custom (3)

DNA Binding (1)

DNA Binding Phosphorylation (3)

Primary (155)

Recombinant (7)

Sandwich (4)

Target

ATF2 (180)

Reactivity

Human (163)

Mouse (102)

Rat (105)

Bat (6)

Bovine (14)

Chicken (20)

Chimpanzee (6)

Dog (7)

Gibbon (6)

Guinea pig (3)

Hamster (6)

Horse (10)

Monkey (14)

Non-Human Primate (1)

Pig (4)

Rabbit (11)

Xenopus (7)

Zebrafish (6)

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Application

IHC (101)

IHC-Fr (1)

IHC-P (34)

WB (142)

Flo (2)

DB (8)

ELISA (59)

ICC (1)

IF (33)

IP (43)

Peptide-ELISA (21)

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Host

rabbit (137)

mouse (16)

goat (1)

sheep (1)

Product Group

IHCPlus (2)

Isotype

IgG (95)

IgG1 (6)

IgG1,k (9)

Clonality

monoclonal mc (15)

polyclonal pc (140)

Clone

103C411.2 (2)

1E12 (1)

4A3 (1)

4F12 (1)

ATF25I062 (1)

Format

12 x 8-Well Microstrips (4)

96-Well Microplate (8)

96-Well Strip Plate (6)

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Azide-free (4)

Biotin Conjugated (7)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (4)

Unconjugated (126)

Epitope

pSer480 (8)

pSer322 (7)

10-90 aa (6)

aa317-347 (6)

N-Terminus (5)

C-Terminus (4)

aa401-450 (4)

aa51-100 (4)

40-120 aa (2)

410-490 aa (2)

430-510 aa (2)

50-130 aa (2)

Internal (2)

pSer112 (2)

pSer472 (2)

pSer498 (2)

pThr52 (2)

pThr71 (2)

pThr71,pThr53 (2)

pThr73 (2)

pThr73/ 55 (2)

Ab-480 (1)

Gly56/39 (1)

Thr51 (1)

Val63/45 (1)

Val65/47 (1)

aa13-27 (1)

aa250-300 (1)

aa29-78 (1)

aa35-84 (1)

aa38-87 (1)

aa40-89 (1)

aa437-487 (1)

aa441-490 (1)

aa456-505 (1)

aa492-505 (1)

aa79-128 (1)

aa93-450 (1)

p112 or 94 (1)

p472 (1)

p51/53 (1)

p62 or 44 (1)

p71 or 53 (1)

p73 or 55 (1)

pSer112 or 94 (1)

pSer112,pSer94 (1)

pSer112/94 (1)

pSer44/62 (1)

pSer490/Ser498 (1)

pSer490/pSer498 (1)

pSer62 (1)

pSer62 or 44 (1)

pSer62,pSer44 (1)

pSer62/44 (1)

pSer94/112 (1)

pThr51/pThr69 (1)

pThr53 (1)

pThr69 (1)

pThr69 or 51 (1)

pThr69,pThr51 (1)

pThr69/51 (1)

pThr69/71 (1)

pThr69/Thr51 (1)

pThr71 or 53 (1)

pThr71/53 (1)

pThr71/Thr53 (1)

pThr73 or 55 (1)

pThr73,pThr55 (1)

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Publications

No (180)

Sample Type

Adherent Cell Cultures (7)

Cell Lysates (4)

Nuclear Lysates (4)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

Tag

GST (1)

GST, N-terminus (2)

His, N-Terminal (1)

His,C-terminus (1)

His-GST (1)

His-SUMO (1)

Species

Human (7)

Source

Baculovirus (1)

E. coli (2)

Sf9 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

IHC-plus™ ATF2 Antibody (clone 4A3) LS-B6524

(4.0) Rating

Antibody:

ATF2 Mouse anti-Human Monoclonal (4A3) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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Human ATF2 Protein (Recombinant His-SUMO) (Full Length) - LS-G20506

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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ATF2 Antibody (aa401-450) LS-C31200

Antibody:

ATF2 Rabbit anti-Human Polyclonal (aa401-450) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

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ATF2 Antibody (aa492-505) LS-C20128

Antibody:

ATF2 Goat anti-Human Polyclonal (aa492-505) Antibody

Reactivity:

Rabbit, Bovine, Pig, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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ATF2 Antibody (phospho-Thr71,pThr53) LS-C808466

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pThr71,pThr53) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATF2 Antibody (phospho-Thr69,pThr51) LS-C808461

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pThr69,pThr51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATF2 Antibody (phospho-Ser62,pSer44) LS-C808458

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pSer62,pSer44) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATF2 Antibody LS-C306429

Antibody:

ATF2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$705

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ATF2 Antibody (Biotin) LS-C520858

Antibody:

ATF2 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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ATF2 Antibody (PE) LS-C649103

Antibody:

ATF2 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$904

• Unconjugated
• Biotin
• PE

• Unconjugated
• Biotin
• PE

Select

ATF2 Antibody (phospho-Thr73,pThr55) LS-C808463

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pThr73,pThr55) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATF2 Antibody (phospho-Ser112,pSer94) LS-C801032

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pSer112,pSer94) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

ATF2 Antibody (phospho-Ser480) LS-C198650

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pSer480) Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ATF2 Antibody (430-510 aa) LS-C381508

Antibody:

ATF2 Rabbit anti-Human Polyclonal (430-510 aa) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ATF2 Antibody LS-C659412

Antibody:

ATF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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ATF2 Antibody LS-C801558

Antibody:

ATF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

IHC-plus™ ATF2 Antibody (Thr51) LS-B1171

(4.0) Rating

Antibody:

ATF2 Rabbit anti-Human Polyclonal (Thr51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

ATF2 Antibody LS-C331946

Antibody:

ATF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

Select

ATF2 Antibody (aa93-450) LS-C343993

Antibody:

ATF2 Rabbit anti-Human Polyclonal (aa93-450) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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ATF2 Antibody (phospho-Ser480) LS-C822180

Antibody:

ATF2 Rabbit anti-Human Polyclonal (pSer480) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF2 Antibody (p112 or 94) LS-C826123

Antibody:

ATF2 Rabbit anti-Human Polyclonal (p112 or 94) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF2 Antibody (p62 or 44) LS-C826125

Antibody:

ATF2 Rabbit anti-Human Polyclonal (p62 or 44) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF2 Antibody (p51/53) LS-C826126

Antibody:

ATF2 Rabbit anti-Human Polyclonal (p51/53) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF2 Antibody (p71 or 53) LS-C826130

Antibody:

ATF2 Rabbit anti-Human Polyclonal (p71 or 53) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF2 Antibody (p73 or 55) LS-C826131

Antibody:

ATF2 Rabbit anti-Human Polyclonal (p73 or 55) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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