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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ARRB1 / Beta Arrestin 1 Antibody (phospho‑Ser412) LS‑C20787
Beta Arrestin 1 antibody LS-C20787 is an unconjugated mouse monoclonal antibody to Beta Arrestin 1 (ARRB1) from human, mouse and rat. Validated for ELISA, IP and WB.
Antibody
Catalog
Size
Price
LS-C20787-100
100 µl
Unavailable

Popular ARRB1 / Beta Arrestin 1 Products

Antibody
Species: Human, Mouse, Rat
Applications: Western blot, ELISA
IHC of paraffin-embedded human brain tissue, using Arrestin 1 (Ab-412) Antibody. The picture on the right is treated with the synthesized peptide.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human
Applications: Immunofluorescence, Western blot
ARRB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry

Product Description

Beta Arrestin 1 antibody LS-C20787 is an unconjugated mouse monoclonal antibody to Beta Arrestin 1 (ARRB1) from human, mouse and rat. Validated for ELISA, IP and WB.
About ARRB1 / Beta Arrestin 1
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. P49407 NM_004041 NP_004032.2

ARRB1 Antibody, Arrestin 2 Antibody, Arrestin beta-1 Antibody, Arb1 Antibody, ARR1 Antibody, Beta-arrestin-1 Antibody, Arrestin, beta 1 Antibody


Specifications

Target
Human ARRB1 / Beta Arrestin 1
Host
Mouse
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • Western blot (1:1000)
  • Immunoprecipitation (1:50)
  • ELISA
Immunogen
Synthetic peptide (KLH coupled) corresponding to residues surrounding Ser412 of human beta-arrestin 1.
Epitope
pSer412
Specificity
Detects endogenous beta-arrestin 1 only when phosphorylated at Ser412. Does not cross-react with beta-arrestin 2. Species cross-reactivity: Mouse and rat.
Usage
Suitable for use in ELISA, Western Blot and Immunoprecipitation. Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4?C with gentle shaking, overnight. Immunoprecipitation: 1:50.
Presentation
10 mM HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/ml BSA, 50% glycerol, 0.02% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/19/2018

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