Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ARNTL, BHLH-PAS protein JAP3, BHLHe5, BMAL1c, JAP3, PASD3, Member of PAS protein 3, MOP3, TIC, Brain and muscle ARNT-like 1, Member of PAS superfamily 3
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Western blot (1:1000 - 1:5000)
ARNTL / BMAL1 antibody was raised against a 15-aa peptide sequence within the C-terminus of Human MOP3 (1) was synthesized coupled to KLH.
Human sequence is 100% conserved in related proteins from other species (rat TIC; human bMAL1a & bMAL1b, PAS3, JAP3 and mouse Arnt3). Antibody cross-reactivity with MOP3 from various species is not known.
Suitable for use in ELISA and Western Blot.
PBS, 0.05% Sodium Azide, 40% Glycerol
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
ARNTL / BMAL1 is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes.
Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver. Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Bladé C, Arola L. Scientific reports. 2015 5:10954. (WB; Human)[Full Text Article]