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ARL6

ADP-ribosylation factor-like 6

Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.

Gene Name: ADP-ribosylation factor-like 6
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARL6, ADP-ribosylation factor-like 6, BBS3, RP55
Target Sequences: NM_032146 NP_115522.1 Q9H0F7

Publications (1)

1
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR. The Journal of biological chemistry. 2010 285:16218-30. [PubMed:20207729] [PMC:PMC2871489]

☰ Filters
Antibodies (12)
Proteins (9)
Over-Expression Lysate (4)
Primary (12)
Recombinant (5)
ARL6 (21)
Human (12)
Mouse (6)
Rat (4)
Bovine (1)
Dog (1)
Guinea pig (1)
Horse (1)
Rabbit (1)
IHC (9)
IHC-P (6)
WB (7)
ELISA (4)
IF (3)
IP (1)
Peptide-ELISA (2)
rabbit (11)
goat (1)
Product Group
IHCPlus (3)
IgG (8)
polyclonal pc (12)
Unconjugated (12)
N-Terminus (1)
aa2-186 (1)
aa38-50 (1)
No (21)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
ARL6 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ARL6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ARL6 Antibody - Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ARL6 Goat anti-Mouse Polyclonal (aa38-50) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Horse, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$460
ARL6 Antibody - Anti-ARL6 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ARL6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ARL6 Antibody - Immunohistochemical analysis of ARL6 staining in human prostate formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ARL6 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
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ARL6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
ARL6 Antibody - Immunohistochemistry of paraffin-embedded human glioma cancer at dilution 1:100
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ARL6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ARL6 Antibody - 1:100 staining human lymph carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ARL6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ARL6 Antibody - Immunohistochemistry of ARL6 antibody
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ARL6 Rabbit anti-Human Polyclonal (aa2-186) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$332
ARL6 Antibody - Immunofluorescence analysis of U2OS cells using ARL6 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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ARL6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
ARL6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ARL6 Antibody - Immunofluorescence analysis of U2OS cells using ARL6 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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ARL6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ARL6 Antibody - Immunochemical staining of human ARL6 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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ARL6 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
ARL6 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ARL6 Protein - Purified recombinant protein ARL6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
ARL6 Protein - Purified recombinant protein ARL6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
ARL6 Protein - 12.5% SDS-PAGE of human ARL6 stained with Coomassie Blue
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Wheat Germ Extract
GST
46.2 kDa
2 µg/$439
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
ARL6 Protein
Select
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
Viewing 1-21 of 21 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).