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Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
Gene Name: | Rho guanine nucleotide exchange factor (GEF) 26 |
Synonyms: | ARHGEF26, DKFZP434D146, HMFN1864, SGEF, CSGEF |
Target Sequences: | NM_015595 NP_056410.3 Q96DR7 |
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