Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Mouse Monoclonal [clone 4G4-D5] (IgG1,k) to Human ARH / LDLRAP1
Human
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
Details
Human ARH / LDLRAP1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [4G4-D5]
Unconjugated
Purified from ascites by Protein A
Unmodified
Applications
IHC
IHC - Paraffin (5 µg/ml)
Immunofluorescence (10 µg/ml)
Western blot
ELISA
Specificity and Use
ARH / LDLRAP1 antibody was raised against lDLRAP1 (AAH29770, 1 a.a. ~ 264 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Western Blot (Cell lysate) - positive control Hela NE. Western Blot (Transfected lysate) - positive control transfected 293T cell line. Immunofluorescence (10 ug/ml) - positive control HeLa cells.
Packaging
PBS, pH 7.4
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits.
Anti-LDLRAP1 antibody IHC of human small intestine, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4523 concentration 5 ug/ml.
Immunohistochemistry
Anti-LDLRAP1 antibody IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4523 concentration 5 ug/ml.
Immunohistochemistry
Anti-LDLRAP1 antibody IHC of human prostate, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4523 concentration 5 ug/ml.
Immunofluorescence
Immunofluorescence of monoclonal antibody to LDLRAP1 on HeLa cell (antibody concentration 10 ug/ml).
Western blot
LDLRAP1 monoclonal antibody, clone 4G4-D5 Western blot of LDLRAP1 expression in HeLa NE.
Western blot
Western blot of LDLRAP1 expression in transfected 293T cell line by LDLRAP1 monoclonal antibody, clone 4G4-D5.