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ARF1

ADP-ribosylation factor 1

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Name: ADP-ribosylation factor 1
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARF1, ADP-ribosylation factor 1
Target Sequences: NM_001658 NP_001649.1 P84077

Publications (1)

1
p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. Luo W, Wang Y, Reiser G. The Journal of biological chemistry. 2007 282:30246-55. (WB) [PubMed:17693410]

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ARF1 Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution of 1:100
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ARF1 Mouse anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$801
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ARF1 Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
HRP Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
FITC Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
PE Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
APC Conjugated
100 µl/$1,027
ARF1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
ARF1 Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ARF1 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ARF1 Polyclonal Antibody at dilution of 1:25.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ARF1 Antibody - ARF1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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ARF1 Mouse anti-Human Monoclonal (FITC) (3F1) Antibody
Human
ICC, IF
FITC Conjugated
0.05 mg/$634
ARF1 Antibody
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ARF1 Mouse anti-Human Monoclonal (AT1B3) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
ARF1 Antibody - Western blot analysis of ARF1 using HT29 whole lysates.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ARF1 Antibody - Immunofluorescence analysis of HeLa cells using ARF1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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ARF1 Mouse anti-Human Monoclonal (4G6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Viewing 1-25 of 56 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).