Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP242] (IgG) to Human AR / Androgen Receptor
IHC - Paraffin
Mouse Monoclonal (IgG1) to Guinea pig AR / Androgen Receptor
IHC - Paraffin, IHC - Frozen, ICC, Western blot
Guinea pig AR / Androgen Receptor
Guinea pig (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen
Specificity and Use
Synthetic peptide from guinea pig AR / Androgen receptor.
Reactive with a 110kD protein in a lysate from the LNCP cell line.
Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry (frozen sections and paraffin-embedded tissue after microwave pretreatment). Immunohistochemistry: 1:5-1:10; Dilute immediately before use with PBS. Positive control: Testis.
PBS, pH 7.4, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility.