Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP242] (IgG) to Human AR / Androgen Receptor
IHC - Paraffin
Mouse Monoclonal [clone MM26-2.1.3] to Human AR / Androgen Receptor
IHC - Paraffin, Western blot, Immunoprecipitation
Human AR / Androgen Receptor
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (1:50)
Western blot (2.5 - 5 µg/ml)
Specificity and Use
AR / Androgen Receptor antibody was raised against synthetic peptide corresponding to a protein sequence from human AR.
Human Androgen Receptor. Does not react with mouse
Immunoprecipitation: 2 ug/mg protein lysate. Immunohistochemistry (formalin fixed paraffin embedded): 1:50 for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10 min followed by cooling at RT for 20 min.
PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at 12 months.
The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility.