APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

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Products

Antibodies (20)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (20)

Recombinant (3)

Target

APPL2 (25)

Reactivity

Human (20)

Mouse (1)

Rat (2)

Application

WB (20)

ELISA (13)

IF (1)

Host

rabbit (9)

mouse (11)

Isotype

IgG (9)

IgG1 (2)

IgG2b (2)

IgG2b,k (6)

Clonality

monoclonal mc (10)

polyclonal pc (10)

Clone

OTI1H8 (1)

OTI3D5 (1)

OTI6G8 (1)

OTI8F1 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (10)

Epitope

aa124-152 (7)

aa174-274 (1)

Publications

No (25)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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APPL2 Antibody (aa174-274) LS-C307868

Antibody:

APPL2 Mouse anti-Human Monoclonal (aa174-274) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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APPL2 Antibody (HRP) LS-C541805

Antibody:

APPL2 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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APPL2 Antibody (Biotin) LS-C521673

Antibody:

APPL2 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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APPL2 Antibody (FITC) LS-C531717

Antibody:

APPL2 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

APPL2 Antibody (PE) LS-C649919

Antibody:

APPL2 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

Select

APPL2 Antibody (APC) LS-C513459

Antibody:

APPL2 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

APPL2 Antibody (aa124-152) LS-C319550

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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APPL2 Antibody (aa124-152, Biotin) LS-C232788

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

APPL2 Antibody (aa124-152, FITC) LS-C232789

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

APPL2 Antibody (aa124-152, APC) LS-C232787

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

APPL2 Antibody (aa124-152, PE) LS-C232791

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

APPL2 Antibody (aa124-152, Azide-free, HRP) LS-C249447

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

APPL2 Antibody LS-C659863

Antibody:

APPL2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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APPL2 Antibody LS-C306307

Antibody:

APPL2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

Select

APPL2 Antibody (clone OTI3D5) LS-C796348

Antibody:

APPL2 Mouse anti-Human Monoclonal (OTI3D5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

APPL2 Antibody (clone OTI6G8) LS-C796349

Antibody:

APPL2 Mouse anti-Human Monoclonal (OTI6G8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

APPL2 Antibody (clone OTI8F1) LS-C796351

Antibody:

APPL2 Mouse anti-Human Monoclonal (OTI8F1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

APPL2 Antibody (clone OTI1H8) LS-C796350

Antibody:

APPL2 Mouse anti-Human Monoclonal (OTI1H8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

APPL2 Antibody (aa124-152) LS-C159098

Antibody:

APPL2 Rabbit anti-Human Polyclonal (aa124-152) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

APPL2 Antibody LS-C749588

Antibody:

APPL2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

Human APPL2 Protein (Recombinant GST, N-terminus) (aa174-273) - LS-G62667

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APPL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71882

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$1,107

Select

Human APPL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90853

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$150

Select

Human APPL2 Protein (Recombinant GST) (Full Length) - LS-G34225

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.9 kDa

Price:

10 µg/$479; 25 µg/$670

Select

APPL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111944

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

100 µg/$494

Viewing 1-25 of 25 product results

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