Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human APP / Beta Amyloid Precursor
Human, Mouse, Rat
Human APP / Beta Amyloid Precursor
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Specificity and Use
APP / Beta Amyloid Precursor antibody was raised against a synthetic peptide corresponding to N-terminal of human APP.
Reacts with a 10 kD protein. This antibody recognizes Amyloid precursor protein (b-APP770). Amyloid precursor protein (APP) and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure. This antibody cross reacts with mouse and rat.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.