Human APP / Beta Amyloid Precursor

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Serum

Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP.

aa292-312

Recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP). Only the APP-751 and APP-770 isoforms contain a KPI domain, it being absent from the APP-695 isoform that is most abundant in neuronal tissue. However, there is evidence that suggests KPI containing isoforms may be important in the pathogenesis of Alzheimer disease. Recognizes a band of ~115kD in NTera2/DI cell lysates using western blotting under reducing conditions.

• IHC - Paraffin (1:400)
• Western blot (1:500 - 1:1000)
• Immunoprecipitation (1:1)

Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin embedded sections. 0.05 M Tris pH7.0, followed by reduction and alkylation is recommended. Histology Positive Control Tissue: Alzheimer's disease brain Western Blot: LS-C42917 detects a band of approximately 115kD in NTera2/DI cell lysates.

0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05067 NCBI: NM_000484 NP_000475.1