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Apolipoprotein A-V

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Gene Name: Apolipoprotein A-V
Synonyms: APOA5, Apo-AV, APOAV, Apolipoprotein A5, Apo-A5, Apolipoprotein A-V, RAP3, ApoA-V
Target Sequences: NM_052968 NP_443200.2 Q6Q788

Publications (4)

1
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM. Science (New York, N.Y.). 2001 294:169-73. [PubMed:11588264]
2
Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. JCI insight. 2018 November;3:pii: 99470. [Full Text Article] [PubMed:30385734] [PMC:PMC6238732]
3
Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma. Oleg Kovrov, Fredrik Landfors, Valeria Saar-Kovrov, Ulf Näslund, Gunilla Olivecrona. Journal of lipid research. 2022 Jan;;63:100144. [Full Text Article] [PubMed:34710432] [PMC:PMC8953621]
4
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations. Marja-Riitta Taskinen, Elias Björnson, Niina Matikainen, Sanni Söderlund, Joel Rämö, Mari-Mia Ainola, Antti Hakkarainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Per-Olof Bergh, Marcus Henricsson, Stefano Romeo, Martin Adiels, Samuli Ripatti, Markku Laakso, Chris J Packard, Jan Borén. JCI insight. 2022 October;7: [Full Text Article] [PubMed:36040803] [PMC:PMC9675484]
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Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$784
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$587
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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Apolipoprotein A-V Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$470
Apolipoprotein A-V Antibody - Anti-APOA5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (1G5G9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Apolipoprotein A-V Antibody - Anti-APOA5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (4H8H8E2) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$460
Apolipoprotein A-V Antibody - Immunohistochemistry of formalin-fixed paraffin-embedded (FFPE) human liver using APOA5 antibody at dilution of 1:100 (40x magnification).
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Apolipoprotein A-V Rabbit anti-Human Monoclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Apolipoprotein A-V Antibody - Western blot of recombinant Apolipoprotein A5 / APOA5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Apolipoprotein A-V Rabbit anti-Mouse Polyclonal (aa21-210) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
Apolipoprotein A-V Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APOA5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APOA5.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (OTI1H4) Antibody
Mouse, Human, Monkey
WB
Unconjugated
100 µl/$434
Apolipoprotein A-V Antibody - Western blot using Apoa5 mouse monoclonal antibody against human serum (A) and Apoa5 recombinant protein (B).
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Apolipoprotein A-V Mouse anti-Human Monoclonal (2G1H11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$595
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
Apolipoprotein A-V Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APOA5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Apolipoprotein A-V Mouse anti-Human Monoclonal (OTI1A1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Apolipoprotein A-V Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APOA5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Apolipoprotein A-V Mouse anti-Human Monoclonal (Carrier-free) (OTI1A1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Apolipoprotein A-V Antibody - Immunohistochemistry image of paraffin-embedded human liver cancer at a dilution of 1:100
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Apolipoprotein A-V Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Apolipoprotein A-V Antibody - Apolipoprotein A5 Antibody in Western Blot (WB)
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Apolipoprotein A-V Mouse anti-Human Monoclonal (2G1H11, 1F1E8) Antibody
Human
IF, WB
Unconjugated
100 µl/$518
Apolipoprotein A-V Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APOA5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APOA5.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (Carrier-free) (OTI1E3) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
Apolipoprotein A-V Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APOA5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APOA5.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (Carrier-free) (OTI2B11) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
Apolipoprotein A-V Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with APOA5 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Apolipoprotein A-V Rabbit anti-Human Polyclonal (aa22-52) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Apolipoprotein A-V Antibody - Anti-APOA5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY APOA5.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (OTI1D1) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
Apolipoprotein A-V Antibody - Anti-APOA5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY APOA5.
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Apolipoprotein A-V Mouse anti-Human Monoclonal (Carrier-free) (OTI1D1) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
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Apolipoprotein A-V Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$583
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Apolipoprotein A-V Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$649
Viewing 1-25 of 136 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).