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Anti-APOE / Apolipoprotein E Antibody (clone WUE-4) LS-C188624


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $355
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular APOE / Apolipoprotein E Antibodies

Anti-APOE / Apolipoprotein E Antibody (N-Terminus) IHC-plus™ LS-B4680
Rabbit Polyclonal (IgG) to Human APOE / Apolipoprotein E
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-APOE / Apolipoprotein E Antibody (clone 1F9) LS-C179798
Mouse Monoclonal [clone 1F9] (IgG1) to Human APOE / Apolipoprotein E
IHC, Western blot, Immunoprecipitation
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100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone WUE-4] (IgG1) to Human APOE / Apolipoprotein E
Western blot, ELISA (applications tested for the base form of this product only)


Human APOE / Apolipoprotein E
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [WUE-4]
Protein G purified


  • Western blot
  • ELISA (1:100 - 1:1000)
  • (applications tested for the base form of this product only)

Specificity and Use

APOE / Apolipoprotein E antibody was raised against purified ApoHDL fraction.
Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone 6-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About APOE / Apolipoprotein E

P02649 NM_000041 NP_000032.1

APOE Antibody, AD2 Antibody, Apo-E Antibody, Apolipoprotein E3 Antibody, Apolipoprotein E Antibody, LDLCQ5 Antibody, LPG Antibody

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2.

Requested From: United States
Date Requested: 10/27/2016

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