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APOA1 / Apolipoprotein A 1
apolipoprotein A-I
APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease.
| Gene Name: | apolipoprotein A-I |
| Synonyms: | APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI |
| Target Sequences: | NM_000039 NP_000030.1 P02647 |
Publications (6)
1
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43.
[PubMed:16418537]
2
A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-1. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4826-32.
[PubMed:16982924]
3
Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B. Human molecular genetics. 2013 22:1289-99. (ICC, IHC; Mouse)
[PubMed:23255163]
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APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal (aa188-199) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$460
APOA1 / Apolipoprotein A 1 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$795
APOA1 / Apolipoprotein A 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, ID, IHC, IHC-P, WB
Unconjugated
125 µg/$755
APOA1 / Apolipoprotein A 1 Mouse anti-Human Monoclonal (aa10-37) (464CT10.4.4) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
APOA1 / Apolipoprotein A 1 Mouse anti-Human Monoclonal (G2) Antibody
Human
ELISA, IHC-Fr, WB
Unconjugated
0.5 mg/$556
APOA1 / Apolipoprotein A 1 Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
0.2 mg/$430
APOA1 / Apolipoprotein A 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$505
APOA1 / Apolipoprotein A 1 Mouse anti-Rabbit Monoclonal (aa25-265) Antibody
Rabbit
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
APOA1 / Apolipoprotein A 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1 mg/$375
APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
Sandwich
96-Well Strip Plate
Pig
1.406 - 90 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich
96-Well Microplate
Human
1.4 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$830
Sandwich
96-Well Strip Plate
Rat
0.21 - 150 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$741
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$705
APOA1 / Apolipoprotein A 1 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat
WB
Unconjugated
100 µl/$424
APOA1 / Apolipoprotein A 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$795
APOA1 / Apolipoprotein A 1 Mouse anti-Human Monoclonal (057-10029) Antibody
Human
ELISA, IHC, IHC-P, RIA
Unconjugated
50 µg/$495
APOA1 / Apolipoprotein A 1 Rabbit anti-Mouse Polyclonal (aa25-264) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
APOA1 / Apolipoprotein A 1 Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
1 ml/$1,295
APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$380
APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal (N-Terminus) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
Sandwich
96-Well Strip Plate
Rabbit
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal (aa10-37) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
APOA1 / Apolipoprotein A 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
APOA1 / Apolipoprotein A 1 Chicken anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
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