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Anti-APEX1 / APE1 Antibody IHC-plus™ LS-B3179

Note: This antibody replaces LS-C11929


Wt. Vol. Conc. Price
- 50 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular APEX1 / APE1 Antibodies

Anti-APEX1 / APE1 Antibody (clone 13B8E5C2) LS-C2600
Mouse Monoclonal [clone 13B8E5C2] (IgG2b) to Human APEX1 / APE1
Human, Mouse, Rat
IHC - Frozen, ICC, Western blot, Immunoprecipitation
Immunocytochemistry Image
Anti-APEX1 / APE1 Antibody (aa2-15) IHC-plus™ LS-B3924
Goat Polyclonal to Human APEX1 / APE1
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image
Anti-APEX1 / APE1 Antibody LS-C136888
Rabbit Polyclonal (IgG) to Human APEX1 / APE1
Western blot, ELISA
Western blot Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal (IgG) to Human APEX1 / APE1
IHC - Paraffin, IHC - Frozen, Western blot


Human APEX1 / APE1
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified


  • IHC - Paraffin (1:250)
  • IHC - Frozen
  • Western blot (1:500)

Specificity and Use

APEX1 / APE1 antibody was raised against affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein.
Specific to the human APE/ref-1protein. Competitively inhibited from recognizing the APE/ref-1 antigen in tissues using APE/ref-1 protein. Inhibits repair activity of ape protein.
Immunohistochemistry: LS-B3179 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3179 was determined to be 1:250. Western Blot: 1:500 (ECL). Detects a single band at 37kD. Diluted antibody can be reused 1-3 times in Western Blot analysis. Apoptosis: Can be used following the apoptosis (TUNEL) procedure using the Boehringer-Mannheim TUNEL assay kit. Antibody staining should be performed AFTER the TUNEL assay. Positive control: HeLa whole cell extract.


PBS, pH 7.2, 0.05% sodium azide before the addition of glycerol to 40%.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

Publications (1)

Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death. Cho KJ, Kim HJ, Park SC, Kim HW, Kim GW. Molecular and cellular neurosciences. 2010 Nov;45:267-76. [Full Text Article] [PubMed:20637286]

About APEX1 / APE1

P27695 NM_001641 NP_001632.2

APEX1 Antibody, AP endonuclease class I Antibody, AP lyase Antibody, APE Antibody, APE-1 Antibody, APEN Antibody, APE1 Antibody, APEX nuclease Antibody, Redox factor-1 Antibody, AP endonuclease 1 Antibody, APEX Antibody, APX Antibody, Protein REF-1 Antibody, REF-1 Antibody, REF1 Antibody

Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.


Anti-APEX1 / APE1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3179 dilution 1:250.


Anti-APEX1 / APE1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3179 dilution 1:250.

Requested From: United States
Date Requested: 10/21/2016

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