APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

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Products

Antibodies (68)

ELISA Kits (23)

Proteins (7)

Type

Cell-Based (1)

Custom (3)

Over-Expression Lysate (3)

Primary (68)

Recombinant (4)

Sandwich (14)

Sandwich CLIA (5)

Target

APAF1 / APAF-1 (98)

Reactivity

Human (67)

Mouse (41)

Rat (25)

C. elegans (4)

Chicken (1)

Dog (1)

Gerbil (2)

Mammal (4)

Monkey (2)

Porcine (1)

Rabbit (1)

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Application

IHC (27)

IHC-Fr (1)

IHC-P (15)

WB (59)

Flo (2)

ELISA (18)

ICC (5)

IF (5)

IP (11)

Peptide-ELISA (2)

Host

rabbit (60)

mouse (5)

rat (3)

Product Group

IHCPlus (3)

Isotype

IgG (30)

IgG1 (2)

IgG1,k (1)

IgG2a,k (3)

IgG2b (2)

Clonality

monoclonal mc (8)

polyclonal pc (60)

Clone

13F11 (1)

18H2 (1)

2E10 (1)

2E12 (1)

2H9A1 (1)

2H9G5 (1)

5C1 (1)

5E11 (1)

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12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (18)

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Biotin Conjugated (5)

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HRP Conjugated (5)

Low Endotoxin (1)

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Epitope

aa31-350 (8)

aa872-1135 (8)

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C-Terminus (2)

aa1-97 (2)

aa12-28 (2)

501-550 aa, Internal (1)

His324 (1)

Internal (1)

Ser320 (1)

aa1-464 (1)

aa1051-1248 (1)

aa289-338 (1)

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Publications

No (97)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (3)

Plasma (9)

Serum (9)

Tissue Homogenates (9)

Tag

8His, N-terminus (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

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IHC-plus™ APAF1 / APAF-1 Antibody (aa1-464, clone 2E12, Low Endotoxin) LS-B12884

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rat anti-Human Monoclonal (aa1-464) (Low Endotoxin) (2E12) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated, Low Endotoxin

Price:

50 µg/$460

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APAF1 / APAF-1 Antibody LS-C284

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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APAF1 / APAF-1 Antibody LS-C148201

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Gerbil, Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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APAF1 / APAF-1 Antibody LS-C285

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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IHC-plus™ APAF1 / APAF-1 Antibody (C-Terminus) LS-B3340

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

250 µl/$485

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IHC-plus™ APAF1 / APAF-1 Antibody (aa289-338) LS-B7591

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (aa289-338) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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APAF1 / APAF-1 Antibody (C-Terminus) LS-C351827

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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APAF1 / APAF-1 Antibody LS-C659197

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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APAF1 / APAF-1 Antibody (clone 2H9A1) LS-C682621

Antibody:

APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9A1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, WB

Format:

Unconjugated

Price:

100 µl/$459

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APAF1 / APAF-1 Antibody LS-C800241

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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APAF1 / APAF-1 Antibody (His324) LS-C175921

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (His324) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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APAF1 / APAF-1 Antibody (aa1-97, clone 13F11) LS-C344794

Antibody:

APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (13F11) Antibody

Reactivity:

Mouse, Rat

Applications:

ELISA, ICC, IP, WB

Format:

Unconjugated

Price:

100 µg/$421

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APAF1 / APAF-1 Antibody (aa1-97, clone 18H2) LS-C344795

Antibody:

APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (18H2) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IP, WB

Format:

Unconjugated

Price:

100 µg/$421

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APAF1 / APAF-1 Antibody LS-C375229

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Human APAF1 / APAF-1 Protein (Over-Expression Lysate 8His, N-terminus) (Asp2-Cys450) - LS-G26690

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

52.6 kDa

Price:

100 µg/$298

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Rat APAF1 / APAF-1 (Sandwich ELISA) ELISA Kit - LS-F8140

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

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APAF1 / APAF-1 Antibody (501-550 aa, Internal) LS-C387145

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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APAF1 / APAF-1 Antibody (clone 2H9G5) LS-C682644

Antibody:

APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9G5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

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APAF1 / APAF-1 Antibody (N-Terminus) LS-C178933

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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APAF1 / APAF-1 Antibody LS-C402084

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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APAF1 / APAF-1 Antibody LS-C69076

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$531

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APAF1 / APAF-1 Antibody (N-Terminus) LS-C121385

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

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APAF1 / APAF-1 Antibody LS-C358645

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Gerbil, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

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APAF1 / APAF-1 Antibody LS-C358643

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

APAF1 / APAF-1 Antibody LS-C358642

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

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