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Anti-ANTXR1 / TEM8 Antibody (aa481-497, clone 200C1339(SB20)) LS-C596

Note: This antibody replaces LS-C92696, LS-C18057

Ordering

Wt. Vol. Conc. Price
100 µg 200 µl 0.5 mg/ml $335
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Mouse Monoclonal [clone 200C1339(SB20)] (IgG1) to Human ANTXR1 / TEM8
Human, Monkey, Dog, Rabbit
Western blot
Unconjugated

Details

Human ANTXR1 / TEM8
Mouse
Human, Monkey, Dog, Rabbit (tested or 100% immunogen sequence identity)
Mouse, Rat, Bat, Pig (at least 90% immunogen sequence identity)
IgG1 Monoclonal [200C1339(SB20)]
Protein G purified

Applications

Western blot (1 - 3 µg/ml)

Specificity and Use

ANTXR1 / TEM8 antibody was raised against this monoclonal antibody was developed by immunizing mice with a synthetic peptide containing amino acids 481-497 (CINFTRVKNNQPAKYPL) of human TEM8. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Panda, Rabbit (100%); Mouse, Rat, Bat, Elephant, Pig (94%); Horse, Opossum (88%).
aa481-497
TEM8 is observed at ~80 kD in western blots of HUVEC cells (Hotchkiss et al, 2005) and as an 80 kD and 85 kD double in human colon cell lysates (Nanada et al, 2004). The size difference is thought to be due to glycosylation as a 70 kD band was seen when cell extracts in Nanda et al (2004) were treated with a glycosidase cocktail. Nanda et al (2004) note a passage dependent loss of TEM8 in HUVEC suggesting that that TEM8 may be a specific marker of the endothelial cell (EC) phenotype which is lost as primary EC's age in culture and de-differentiate.

Packaging

PBS, 0.2% gelatin, 0.05% sodium azide.
Long term: -70°C; Short term: +4°C
For research use only.

About ANTXR1 / TEM8

Q9H6X2 NM_018153 NP_060623.2

ANTXR1 Antibody, Tumor endothelial marker 8 Antibody, Anthrax toxin receptor 1 Antibody, TEM8 Antibody

ANTXR1 / TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells.

Western blot

Western blot
Western blot detection of TEM8 in TEM8 transfected cell lysate using antibody at 1 ug/ml.
 

Requested From: United States
Date Requested: 9/26/2016

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