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ANO1 / DOG1 / TMEM16A
anoctamin 1, calcium activated chloride channel
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
| Gene Name: | anoctamin 1, calcium activated chloride channel |
| Synonyms: | ANO1, Oral cancer overexpressed 2, Transmembrane protein 16A, ORAOV2, Anoctamin-1, DOG1, TAOS2, TMEM16A |
| Target Sequences: | NM_018043 NP_060513.5 Q5XXA6 |
Publications (2)
1
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P. Cancer discovery. 2015 5:304-15. (IHC; Human)
[Full Text Article]
[PubMed:25572173]
[PMC:PMC4355391]
2
Suppression of CaMKIIß Inhibits ANO1-Mediated Glioblastoma Progression. Kyoung Mi Sim, Young-Sun Lee, Hee Jin Kim, Chang-Hoon Cho, Gwan-Su Yi, Myung-Jin Park, Eun Mi Hwang, Jae-Yong Park. Cells. 2020 April;9: [Full Text Article]
[PubMed:32357567]
[PMC:PMC7290681]
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Antibodies
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Type
Primary
(88)
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Target
ANO1 / DOG1 / TMEM16A
(89)
Reactivity
Human
(81)
Mouse
(17)
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(9)
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(3)
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(3)
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(15)
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(2)
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(29)
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(45)
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(48)
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(1)
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(30)
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(14)
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(11)
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(8)
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(6)
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monoclonal mc
(40)
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(44)
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(4)
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006
(1)
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(2)
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(2)
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(5)
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(5)
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(2)
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(2)
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(5)
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(67)
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(18)
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(8)
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(7)
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(7)
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(5)
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(4)
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(2)
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(2)
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(1)
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(1)
aa927-943
(1)
Publications
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(89)
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(1)
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa828-877) Antibody
Human
WB
Unconjugated
100 µl/$424
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ANO1 / DOG1 / TMEM16A Rabbit anti-Mouse Polyclonal (aa20-239) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI1C8) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (Carrier-free) (OTI1C8) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$511
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Recombinant Monoclonal (RBT-DOG1) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$363
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa904-986) (DOG-1.1) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
Cancer Pathology
Cancer
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Recombinant Monoclonal (aa 2-101) (DG1/2564R) Antibody
Human
IHC-Fx
Unconjugated
100 µg/$525
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI5H7) Antibody
Human
WB
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (Carrier-free) (OTI5H7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa453-482) Antibody
Human
WB
Unconjugated
400 µl/$393
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa927-943) Antibody
Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (tDAN4) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Monoclonal (Preservative Free) (006) Antibody
Human
WB
Unconjugated, Preservative Free
100 µl/$412
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$440; 200 µl/$468
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (890-970 aa, C-terminal) Antibody
Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$331
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa904-986) (DOG1.1) Antibody
Human
IHC, IHC-P
Unconjugated
100 µg/$471
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI1H2) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa921-970) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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