Products

Research Areas

COVID-19

Resources

Quick Order

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

Cart

Products

Antibodies

All Antibodies Primary Antibodies Secondary Antibodies IHC-plus™ Antibodies PathPlus™ Antibodies Isotype Control Antibodies

ELISA and Assay Kits

All Kits Assay Kits Traditional ELISA Kits Cell-Based ELISA Kits DNA-Binding ELISA Kits Phospho-Specific ELISA Kits ELISA Development Kits Chemiluminescent CLIA Kits

Proteins

All Proteins Recombinant Proteins Native Proteins Over-Expression Lysates Bio-Active Proteins Animal-Free Proteins Synthetic Peptides Cell and Tissue Lysates

Research Areas

Cancer Research

Breast Cancer IHC Colorectal Cancer IHC Lung Cancer IHC Prostate Cancer IHC

Pathways And Groups

Apoptosis Caspases Chemokines

Infectious Disease

Virology Coronaviridae (COVID-19) Hepatitis Viruses Herpesviridae (Herpes) Orthomyxoviridae (Influenza) Papillomaviridae (HPV) Paramyxoviridae (Mumps) Pneumoviridae (RSV) Polyomaviridae (SV40) Retroviridae (HIV) Togaviridae (Measles)

Neurodegenerative Disease

Alzheimer's Disease

COVID-19

Coronavirus Detection Coronavirus and COVID-19 Inhibitors Coronavirus Antibodies, Proteins, and cDNAs Cytokine Release Syndrome General Coronavirus Information

Resources

Purchasing

Product Ordering Terms and Conditions Holiday Schedule About the LSBio Guarantee About Reviews

Reference Material

About LSBio (LifeSpan BioSciences Inc.) About Our IHC Validation Process About Our IHC-plus™ Immunohistochemistry Protocol About Our Protocols LSBio ELISA Kit Development Guide Media

Secure Logins

How To Buy

Locations

Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464

Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers

Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us

Additional Contact Details

Distributors

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

AML1 / RUNX1

runt-related transcription factor 1

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

Gene Name:	runt-related transcription factor 1
Synonyms:	RUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB
Target Sequences:	NM_001754 NP_001745.2 Q01196

Publications (7)

TNF-a signaling regulates RUNX1 function in endothelial cells. Hannah A B Whitmore, Dhanesh Amarnani, Michael O'Hare, Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Julien Pedron, John H Bushweller, Joseph F Arboleda-Velasquez, Leo A Kim. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 November; [Full Text Article] [PubMed:33135824] [PMC:PMC7821222] Related Antibodies: LS-B13948.

Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, Elizabeth J Rossin, Dean Eliott, John B Miller, Whitney A Greene, Leslie Ramos, Said Arevalo-Alquichire, David Leyton-Cifuentes, Lucia Gonzalez-Buendia, Daniela Isaacs-Bernal, Hannah A B Whitmore, Natalia Chmielewska, Brandon V Duffy, Eric Kim, Heuy-Ching Wang, Jose M Ruiz-Moreno, Leo A Kim, Joseph F Arboleda-Velasquez. Scientific reports. 2020 November;10:20554. [Full Text Article] [PubMed:33257736] [PMC:PMC7705016] Related Antibodies: LS-B13948.

Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer. Yujin Kim, Bo Bin Lee, Dongho Kim, Sangwon Um, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim. Journal of Clinical Medicine. 2020 June;9: [Full Text Article] [PubMed:32498288] [PMC:PMC7356912] Related Antibodies: LS-B5382.

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Michael O'Hare, Dhanesh Amarnani, Hannah A B Whitmore, Miranda An, Claudia Marino, Leslie Ramos, Santiago Delgado-Tirado, Xinyao Hu, Natalia Chmielewska, Anita Chandrahas, Antonia Fitzek, Fabian Heinrich, Stefan Steurer, Benjamin Ondruschka, Markus Glatzel, Susanne Krasemann, Diego Sepulveda-Falla, David Lagares, Julien Pedron, John H Bushweller, Paul Liu, Joseph F Arboleda-Velasquez, Leo A Kim. The American journal of pathology. 2021 Jul;;191:1193-1208. [Full Text Article] [PubMed:33894177] [PMC:PMC8059259] Related Antibodies: LS-B13948.

Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R Reynolds, Anthoula Lazaris, Peter Metrakos. Communications biology. 2021 Aug;4:950. [Full Text Article] [PubMed:34376784] [PMC:PMC8355374] Related Antibodies: LS-C353932.

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis. Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Dhanesh Amarnani, Daniela Isaacs-Bernal, Hannah Whitmore, Said Arevalo-Alquichire, David Leyton-Cifuentes, Jose M Ruiz-Moreno, Joseph F Arboleda-Velasquez, Leo A Kim. Ophthalmology science. 2022 September;2: [Full Text Article] [PubMed:36213726] [PMC:PMC9536424] Related Antibodies: LS-B13948.

The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases. Miran Rada, Nour Hassan, Anthoula Lazaris, Peter Metrakos. Frontiers in oncology. 2022 November;12:1004793. [Full Text Article] [PubMed:36330498] [PMC:PMC9623070] Related Antibodies: LS-C353932.

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Family of Companies