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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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AMICA / JAML
adhesion molecule, interacts with CXADR antigen 1
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
| Gene Name: | adhesion molecule, interacts with CXADR antigen 1 |
| Synonyms: | AMICA1, AMICA, CREA7-1, CREA7-4, Adhesion molecule AMICA, Gm638, Junctional adhesion molecule, JAML |
| Target Sequences: | NP_694938.2 Q86YT9 |
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