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Alpha Tubulin

Tubulin Alpha

Tubulin can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. The tubulin superfamily contains six families of tubulins (alpha-, beta-, gamma-, delta-, epsilon and zeta-tubulins). Tubulin is also used to specifically refer to alpha-tubulin and beta-tubulin, the proteins that make up microtubules in eukaryotic cells. Each has a molecular weight of approximately 50,000 Daltons. Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be related to tubulin. Human a-tubulin subtypes include: TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8.

Alpha Tubulin Target Details

Target Name:

Tubulin Alpha

Publications (20)

Carboxy-terminal regions on the surface of tubulin and microtubules. Epitope locations of YOL1/34, DM1A and DM1B. Breitling F, Little M. Journal of molecular biology. 1986 189:367-70. [PubMed:2427729]

The role of microtubules in platelet secretory release. Berry S, Dawicki DD, Agarwal KC, Steiner M. Biochimica et biophysica acta. 1989 1012:46-56. [PubMed:2730897]

10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin. Blose SH, Meltzer DI, Feramisco JR. The Journal of cell biology. 1984 98:847-58. [PubMed:6538204] [PMC:PMC2113126]

G protein binding and G protein activation by nucleotide transfer involve distinct domains on tubulin: regulation of signal transduction by cytoskeletal elements. Roychowdhury S, Wang N, Rasenick MM. Biochemistry. 1993 32:4955-61. [PubMed:8490031]

Proteomic studies on low- and high-grade human brain astrocytomas. Odreman F, Vindigni M, Gonzales ML, Niccolini B, Candiano G, Zanotti B, Skrap M, Pizzolitto S, Stanta G, Vindigni A. Journal of proteome research. 4:698-708. [PubMed:15952716]

Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons. French RL, Heberlein U. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:20924-9. [PubMed:19923438] [PMC:PMC2791575]

Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR. Journal of immunology (Baltimore, Md. : 1950). 2011 186:2127-37. [PubMed:21220695] [PMC:PMC3088479]

p53 in trichostatin A induced C6 glioma cell death. Hsu YF, Sheu JR, Hsiao G, Lin CH, Chang TH, Chiu PT, Wang CY, Hsu MJ. Biochimica et biophysica acta. 2011 1810:504-13. [PubMed:21376104]

Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia. Slupianek A, Dasgupta Y, Ren SY, Gurdek E, Donlin M, Nieborowska-Skorska M, Fleury F, Skorski T. Blood. 2011 118:1062-8. [PubMed:21653319] [PMC:PMC3148158]

Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. Kadiu I, Gendelman HE. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2011 6:658-75. (ICC; Human) [PubMed:21789505] [PMC:PMC3232570]

Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages. Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR. The Journal of biological chemistry. 2011 286:34830-8. [PubMed:21849499] [PMC:PMC3186414]

MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. Hsu YF, Sheu JR, Lin CH, Chen WC, Hsiao G, Ou G, Chiu PT, Hsu MJ. Biochimica et biophysica acta. 2011 1810:1160-9. [PubMed:21911040]

TEX11 modulates germ cell proliferation by competing with estrogen receptor for the binding to HPIP. Yu YH, Siao FP, Hsu LC, Yen PH. Molecular endocrinology (Baltimore, Md.). 2012 26:630-42. (WB; Mouse) [PubMed:22383461]

Impact of partial urethral obstruction on bladder function: time-dependent changes and functional correlates of altered expression of Ca signaling regulators. Burmeister D, AbouShwareb T, D'Agostino R, Andersson KE, Christ GJ. American journal of physiology. Renal physiology. 2012 302:F1517-28. (WB; Rat) [PubMed:22442207]

Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction. Raman AV, Pitts MW, Seyedali A, Hashimoto AC, Seale LA, Bellinger FP, Berry MJ. Genes, brain, and behavior. 2012 11:601-13. (WB; Mouse) [PubMed:22487427] [PMC:PMC3389215]

Hydrodynamic stretching of single cells for large population mechanical phenotyping. Gossett DR, Tse HT, Lee SA, Ying Y, Lindgren AG, Yang OO, Rao J, Clark AT, Di Carlo D. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:7630-5. (ICC; Human) [PubMed:22547795] [PMC:PMC3356639]

Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ. Molecular and cellular biology. 2012 32:4141-54. (WB; Mouse) [PubMed:22890841] [PMC:PMC3457337]

Herpes simplex virus 34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells. Gobeil PA, Leib DA. mBio. 2012 3:e00267-12. (WB; Mouse) [PubMed:23073763] [PMC:PMC3470650]

Vascular disrupting effect of CKD-516: preclinical study using DCE-MRI. Wu H, Stanley JR, Cotsarelis G. Investigational new drugs. 2013 (ICC, IHC-Fr; Rabbit, Human) [PubMed:23299389]

Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701] Related Antibodies: LS-B3664.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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