Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Mouse (at least 90% immunogen sequence identity)
Western blot (1:500 - 1:3000)
Specificity and Use
ALKBH1 / ALKB antibody was raised against recombinant fragment corresponding to a region within amino acids 166 and 387 of ABH1 (SwissProt Q13686). Percent identity by BLAST analysis: Human (100%); Mouse (90%).
Human ALKBH1 / ALKB
0.1 M Tris-glycine, pH 7.0, 20% glycerol, 0.01% Thimerosal
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
ALKBH1 Antibody, ABH Antibody, ABH1 Antibody, ALKBH Antibody, Alkb protein homolog Antibody, HABH Antibody, AlkB Antibody, DNA lyase ABH1 Antibody
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.